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Shop By Category Antibiotics & Selection | Anti-cancer

Gold Biotechnology is committed to carrying only the highest grade anti-cancer or chemotherapeutic products for the cancer research field. Our cancer research reagents include apoptosis inducers, antitumor antimicrobials, growth factor inhibitors, drug precursors, dyes and stains. GoldBio provides the best quality cancer research reagents so that you can develop the best chemotherapeutic research strategies.
Displaying 1-20 of 73 results.
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10-Deacetyl Baccatin III
Catalog ID
Size
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10-Deacetyl Baccatin III product image
D-550-5
5 mg
$ 178.00
D-550-25
25 mg
$ 669.00
Description

10-Deacetyl baccatin III is an intermediate in the synthesis of the chemotherapeutic drug, paclitaxel (taxol). It is produced by and isolated from Taxus baccata. 10-Deacetyl baccatin III is an immiscible organic compound.

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Specifications
CAS Number 32981-86-5
Technical Resources
17-AAG
Catalog ID
Size
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17-AAG product image
A-950-500
500 μg
$ 40.00
A-950-1
1 mg
$ 58.00
A-950-5
5 mg
$ 150.00
Description

17-AAG (17-N-allylamino-17-demethoxygeldanamycin) is an antitumor agent derived from geldanamycin. It is studied for its role in the treatment of cancer. 17-AAG targets and inactivates Hsp90 (heat shock protein 90), which is expressed in a variety of cancer cells including lymphoma and leukemia. It has been shown to induce apoptosis in ALCL cells and cause c-Kit inhibition. 17-AAG has 100x more affinity for cancer cell Hsp90 than noncancer cell Hsp90.

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Specifications
CAS Number 75747-14-7
Technical Resources
5-Fluorouracil
Catalog ID
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5-Fluorouracil product image
F-440-5
5 g
$ 72.00
Description
5-Fluorouracil (5-FU) is a uracil analog that has a fluorine atom on the fifth carbon position. It acts as a strong anti-cancer agent where its metabolization disrupts both RNA and DNA synthesis. 5-FU metabolites, Fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine triphosphate (FUTP), imitate uracil and are incorporated into RNA strands which effectively inhibits further synthesis.Inhibition of DNA synthesis by 5-FU occurs through thymidylate synthase inhibition. A metabolite produced by 5-FU metabolism, fluorodeoxyuridine triphosphate (FdUTP), bind to the nucleotide binding site of thymidylate synthase. Halting this enzyme’s activity significantly diminishes deoxythymidine monophosphate (dTMP) production which consequently depletes dTMP within an organism.Product Specifications5-FluorouracilFluorouracilFormula: View product page →
Specifications
CAS Number 51-21-8
Technical Resources
8-Hydroxyquinoline
Catalog ID
Size
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8-Hydroxyquinoline product image
H-605-100
100 g
$ 69.00
H-605-500
500 g
$ 235.00
Description
8-Hydroxyquinoline is an organic compound that is used as a RNA inhibitor, anti-cancer agent and bidentate chelating agent. In vitro studies against Escherichia coli had shown 8-hydroxyquinoline inhibiting RNA polymerase activity. The enzyme’s activity was inhibited by chelating manganese, magnesium or zinc cofactors. Activity of 8-hydroxyquinoline toward RNA polymerase is broad and inhibits the synthesis of vertebrate RNA as well as proteins.8-Hydroxyquinoline has also been used as an immobile chelating agent to remove transition metals, alkali and alkaline cations from solutions or within organisms. Its capability to bind the positively charged metals has been shown in vivo to inhibit proteasome View product page →
Specifications
CAS Number 148-24-3
Technical Resources

No resources are available for this product.

Acalabrutinib
Catalog ID
Size
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Acalabrutinib product image
A-415-10
10 mg
$ 150.00
Description
Acalabrutinib (ACP-196) is an irreversible inhibitor of Bruton’s tyrosine kinase (BTK), which is responsible for the maturation of B-cells. Its high selectivity to bind the residue Cys481 in the active site of BTK is a sought after feature for oncology research. Studies on mice and human cells demonstrate the high affinity of ACP-196 and its low affinity toward similar proteins in T-cell maturation.Product SpecificationsAcalabrutinibACP-196Formula: C26H23N7O2 MW: 465.51 g/molStorage/Handling: View product page →
Specifications
CAS Number 1420477-60-6
Technical Resources

No resources are available for this product.

Acriflavine HCl
Catalog ID
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Acriflavine HCl product image
A-905-25
25 g
$ 53.00
Description
Acriflavine HCl is a compound predominantly used in cellular biology for fluorescence staining. It intercalates between the base pairs of DNA and RNA. Among the acridine dyes, acriflavine has the highest affinity for DNA. Acriflavine stains eukaryotic cells exceptionally well in humic substance environments. It provides a robust experimental consistency and reduces the effect of minor experimental errors. The binding of acriflavine to DNA can be observed from a characteristic red shift in an absorption spectrum. While having a high affinity for DNA, acriflavine is limited to euchromatin for both DNA and RNA. Acriflavine has also been found to inhibit heterodimeric View product page →
Specifications
CAS Number 8063-24-9
Technical Resources
Actinomycin D, USP Grade
Catalog ID
Size
Pricing
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A-360-10
10 mg
$ 128.00
A-360-25
25 mg
$ 219.00
Description
Actinomycin D is an antineoplastic antibiotic from Streptomyces species that inhibits cell proliferation by acting as a cytotoxic inducer of apoptosis against tumor cells, binding to DNA and inhibiting RNA polymerase activity. Actinomycin is also used in plant tissue culture to inhibit plant growth through tissue deformation where it also acts as an RNA-synthesis inhibitor. Along with its fluorescent derivative, 7aminoactinomycinD (7-AAD), Actinomycin is used to stain GC-rich regions of DNA for microscopy and flow cytometry applications. Product SpecificationsActinomycin DFormula: C62H86N12O16MW: 1255.41 g/molStorage/Handling: Store at -20°C.PubChem Chemical ID: 457193 View product page →
Specifications
CAS Number 50-76-0
Technical Resources

No resources are available for this product.

Albendazole
Catalog ID
Size
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Albendazole product image
A-210-100
100mg
$ 46.00
A-210-10
10 g
$ 56.00
Description
Albendazole is a benzimidazole derivative typically used as a comprehensive antiparasitic belonging to the anthelminthic group and works by disrupting microtubule formation. Microtubule disruption diminishes glucose transport which increases glycogen catabolism. Eventually, this net loss of energy results in tissue death.The resulting tissue death caused by microtubule formation is a sought after mechanism in oncology research. In vitro research of albendazole on HNSCC (head and neck squamous cancer cells) had shown cell cycle arrest in G2/M stage, resulting in apoptosis. Disruption of microtubule formation also prevented malignant cell migration.Product SpecificationsAlbendazoleMethyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl) carbamateFormula: C12H15N3O2S MW: 265.33 g/molStorage/Handling: View product page →
Specifications
CAS Number 54965-21-8
Technical Resources

No resources are available for this product.

Amygdalin
Catalog ID
Size
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Amygdalin product image
A-570-100
100 g
$ 152.00
A-570-250
250 g
$ 275.00
A-570-500
500 g
$ 442.00
A-570-1000
1 kg
$ 817.00
Description

Amygdalin is a glucoside derived from almonds and apricot kernels. While it was originally suggested that amygdalin is an anticancer agent, it is avoided due to its cyanogenic properties. Upon being metabolized by β-glucosidase enzymes, amygdalin produces hydrogen cyanide, which is cytotoxic on tumor cells. Amygdalin is freely soluble in aqueous solution and is used to study cytotoxic effects of cyanide on cancer cells and can be useful in identification and analysis of maltases, emulsins, and β-glucosidases.

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Specifications
CAS Number 29883-15-6
Technical Resources
Artesunate
Catalog ID
Size
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Artesunate product image
A-670-100
100 mg
$ 84.00
A-670-500
500 mg
$ 293.00
Description
Artesunate is a synthetic compound that is highly employed for its anti-malarial capabilities and is currently studied for its applications in oncology research and surgical procedures. In anti-malarial studies, it has been shown to disrupt EXP1 activity, which is a glutathione transferase responsible for cell detoxification in Plasmodium falciparum. Artesunate activity has been shown to be enhanced when co-administered with amodiaquine HCl (GoldBio Catalog #A-575).In oncology research, Artesunate is used to arrest cancer growth in the G2/M phase and upregulate proteins p21 and Beclin1. These proteins are mainly related to apoptosis with p21 being a regulator of the process and View product page →
Specifications
CAS Number 88495-63-0
Technical Resources

No resources are available for this product.

Baicalin
Catalog ID
Size
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Baicalin product image
B-415-1
1 g
$ 195.00
Description
Baicalin is a flavone glycoside formed from the glucuronidation of baicalein. It has an array of properties which include promoting cell survival and bolstering the immune system. One of the effects that baicalin produced with in vitro studies of pathogens and in vivo studies on rats and mice was an elevation in cell survival, which implied the prevention of cell death due to induced apoptosis or the accumulation of oxidative species. Apoptotic repression occurred in rats due to a decreased expression of proteins within the CHOP (C/EBP homologous protein) pathway. Stimulating the synthesis of endothelial nitrogen oxides (eNOS) and other View product page →
Specifications
CAS Number 21967-41-9
Technical Resources

No resources are available for this product.

Bakuchiol
Catalog ID
Size
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Bakuchiol product image
B-700-5
5 mg
$ 51.00
Description
Bakuchiol is a terpenophenolic compound extracted from the plant Psoralea corylifolia. Bakuchiol has been used as an oral antibiotic, anti-tumor agent and for the protection of liver and bone tissue. It has also been used as an insulin enhancer to counter hyperglycemia and hyperlipidemia for in vivo research on mice and rats. Within these studies, bakuchiol inhibited phospho-tyrosine protein phosphatase type 1B (PTP1B), DNA polymerase and topoisomerase II. Inactivity of these three enzymes greatly reduced PTPB1 activity, which has been found to suppress insulin signaling. Antibiotic and anti-tumor uses of bakuchiol have been shown to be correlated to suppression of View product page →
Specifications
CAS Number 10309-37-2
Technical Resources

No resources are available for this product.

Bevacizumab
Catalog ID
Size
Pricing
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B-600-5
5 mg
$ 417.00
Description
Bevacizumab is a humanized murine anti-VEGF monoclonal antibody that is used in oncology research. It has been used to inhibit vascular endothelial growth factor type A (VEGF-A) expression. Also, bevacizumab has been shown to specifically bind VEGF-A, limiting adverse reactions with other chemotherapeutic agents.Bevacizumab inhibits VEGF-A by binding to the Gly88 residue of VEGFs. Inhibition of VEGF-A suppresses vascular growth from the circulatory and lymphatic systems, decreasing access to nutrients and leading to tumor death. It has also been shown that inhibition of VEGF expression lowers apoptotic pathway regulation, promoting apoptosis in cancerous cells.Product SpecificationsBevacizumabFormula: C6638H10160N1720O2108S44 MW: 149 kDaStorage/Handling: View product page →
Specifications
CAS Number 216974-75-3
Technical Resources
Bithionol
Catalog ID
Size
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Bithionol product image
B-560-50
50 mg
$ 46.00
Description
Bithionol is an anti-parasitic compound used for oncology research and molecular biology research. It induces apoptosis in cancerous cells occurs through activating proteolytic caspases. These caspases inactivate PARP-1(Poly [ADP-ribose] polymerase 1) which triggers an intrinsic pathway for apoptosis. Intrinsic apoptotic pathways result in compromising mitochondria and in this case by decreasing transmembrane potential. Reactive oxygen species then accumulate and rupture the mitochondria, releasing cytochrome c an apoptotic inducer.Bithionol has been used to better understand enzyme allosteric regulation and the mechanism of soluble adenylyl cyclase inhibition, a bicarbonate sensor. Bithionol has been shown to occupy the bicarbonate binding site on soluble View product page →
Specifications
CAS Number 97-18-7
Technical Resources

No resources are available for this product.

Bleomycin A5 hydrochloride
Catalog ID
Size
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Bleomycin A5 hydrochloride product image
B-405-10
10 mg
$ 77.00
B-405-100
100 mg
$ 200.00
B-405-250
250 mg
$ 437.00
Description
Bleomycin A5 hydrochloride is a compound part of the glycopeptide antibiotic family. It is currently used in oncology research for its strong stimulatory and inhibitory effects. Bleomycin A5 greatly reduces telomerase activity, hindering the proliferation of malignant cells. It has also been shown to induce in vivo fibrosis and inflammation by generating peroxynitrites, a strong oxidizing agent.Bleomycin A5 stimulates downstream apoptosis by increasing cysteine-aspartic acid protease-3 (caspase-3) activity, tumor protein 53 (p53) production and transforming growth factor beta 1 (TGF-beta 1) formation. These proteins induce apoptosis directly or indirectly by halting cell growth.Product SpecificationsBleomycin A5 hydrochloridePingyangmycin1-Bleomycinoic acid hydrochlorideFormula: C57H89N19O21S2 View product page →
Specifications
CAS Number 55658-47-4
Technical Resources

No resources are available for this product.

Bleomycin Sulfate, USP Grade
Catalog ID
Size
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Bleomycin Sulfate, USP Grade product image
B-910-10
10 mg
$ 115.00
B-910-50
50 mg
$ 399.00
Description

Bleomycin Sulfate is an anti-cancer agent isolated from Streptomyces verticillus. Bleomycin is a mixture of bleomycin A2 and bleomycin B2, in an approximately 2:1 ratio, respectively. However, the ratio varies by lot number.

Bleomycin is used against Hodgkin’s lymphoma. Its mechanism is not well understood; however, it is though that bleomycin chelates metallic ions causing a decrease in enzyme stability. The enzymes react with oxygen and produce free radicals, ultimately causing single-stranded breaks in deoxyribose sugars of DNA.

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Specifications
CAS Number 9041-93-4
Technical Resources
Brefeldin A
Catalog ID
Size
Pricing
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Brefeldin A product image
B-930-5
5 mg
$ 91.00
B-930-50
50 mg
$ 334.00
Description

Brefeldin A is an antibiotic derived from Penicillium brefeldianum. It is an anti-cancer agent which disrupts protein transport and causes apoptosis of tumor cells. Brefeldin A disrupts the function of the Golgi apparatus and blocks Golgi-COPI activity. ER vesicles are prevented from fusion with the Golgi and are secretion is inhibited. Additionally, Brefeldin A is an ARF inhibitor, sphingomyelin cycle activator, and caspase-3 activator. It has been shown to induce apoptosis in leukemia cells and colon cancer cells.

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Specifications
CAS Number 20350-15-6
Technical Resources
Camptothecin (Camptotheca acuminata)
Catalog ID
Size
Pricing
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Camptothecin (Camptotheca acuminata) product image
C-705-50
50 mg
$ 51.00
C-705-100
100 mg
$ 82.00
C-705-250
250 mg
$ 185.00
Description
Camptothecin is an alkaloid compound used as an anti-cancer agent. It is a topoisomerase I inhibitor in DNA synthesis. Camptothecin has been shown to bind and stabilize a topoisomerase I-DNA complex in vitro, preventing the enzyme from reannealing DNA strands. This inhibition specifically effects the S-phase of cell development and ultimately results in apoptosis due to damaged DNA.Camptothecin is produced by endosymbiotic fungi, from the division Ascomycota (Phycomycete), that are present in the tree Camptotheca acuminata which is native to southern China. Camptothecin (Mappia foetida), (GoldBio Catalog # C-565) has also been isolated from fungi on Mappia foetida (Nothapodytes foetida), View product page →
Specifications
CAS Number 7689-03-4
Technical Resources
Camptothecin (Mappia foetida)
Catalog ID
Size
Pricing
More Info
Camptothecin (Mappia foetida) product image
C-565-50
50 mg
$ 51.00
C-565-100
100 mg
$ 82.00
C-565-250
250 mg
$ 185.00
Description
Camptothecin is an alkaloid compound used as an anti-cancer agent. It is a topoisomerase I inhibitor in DNA synthesis. Camptothecin has been shown to bind and stabilize a topoisomerase I-DNA complex in vitro, preventing the enzyme from reannealing DNA strands. This inhibition specifically effects the S-phase of cell development and ultimately results in apoptosis due to damaged DNA.Camptothecin is found in Mappia foetida (Nothapodytes foetida), a plant native to eastern India. The compound itself is produced by an endosymbiotic Ascomycota (Phycomycete) fungi. Camptothecin (Camptotheca acuminata), (GoldBio Catalog # C-705) has also been produced by endosymbiotic fungi present in Camptotheca acuminata, View product page →
Specifications
CAS Number 7689-03-4
Technical Resources

No resources are available for this product.

Camptothecin sodium
Catalog ID
Size
Pricing
More Info
Camptothecin sodium product image
C-605-50
50 mg
$ 54.00
C-605-100
100 mg
$ 86.00
C-605-250
250 mg
$ 195.00
Description
Camptothecin sodium is sodium salt of an alkaloid compound camptothecin, which is used for cancer research. Camptothecin is produced from endosymbiotic Ascomycota (Phycomycete) fungi present in the tree Camptotheca acuminata or the plant Mappia foetida.Camptothecin sodium is a topoisomerase I inhibitor in DNA synthesis. It has been shown to bind and stabilize a topoisomerase I-DNA complex in vitro, preventing the enzyme from reannealing DNA strands. This inhibition specifically effects the S-phase of cell development and ultimately results in apoptosis due to damaged DNA.Product SpecificationsCamptothecin sodiumCamptothecin sodium saltSodium camptothecinFormula: C20H17N2NaO5 MW: 388.35 g/molStorage/Handling: View product page →
Specifications
CAS Number 25387-67-1
Technical Resources

No resources are available for this product.

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