Amyloids

Amyloids are improperly folded, nonspecific polypeptides, which aggregate into insoluble fibrils, predominantly consisting of β-sheets. These fibrils can accumulate in organs, disrupting normal function, a condition known as amyloidosis. Amyloidosis is often associated with neurodegenerative disorders such as Alzheimer and Parkinson’s disease. Amyloid fibrils are very stable structures, with mechanical strength comparable to steel, despite being bound and polymerized by noncovalent interactions. Because of this stability, they are also of interest in the design of biodegradable protein-based polymers. GoldBio provides high-quality recombinant rhesus macaque serum amyloid A1 at an affordable price.
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SAA1, Rhesus Macaque

Catalog ID Size Pricing
2250-01-2 2 μg $ 76.00
2250-01-10 10 μg $ 112.00

Description

SAA1 is a positive acute phase apolipoprotein reactant that associates with HDL. It is expressed predominantly by hepatocytes in the liver and secreted into plasma, but is also expressed and secreted by adipocytes, endothelial cells, and peripheral monocytes. Expression of SAA1 is induced by LPS and by a variety of cytokines such as IL1, IL6, and TNF. Induction causes a dramatic increase of SAA1 levels in blood, indicating that it may play a short-term role in response to injury and inflammation. SAA1 can aggregate into insoluble fibrils that are deposited in various tissues or organs and disrupt normal function, a condition known as amyloidosis. Amyloidosis of SAA1 is associated with rheumatoid arthritis. SAA1 induces the synthesis of a variety of cytokines and proteinases and inhibits proliferation of endothelial cells. When not bound to HDL, it is chemotactic for monocytes, phagocytes, CD4(+) and CD8(+) T-cells, and polymorphonuclear leukocytes. SAA1 is a ligand for CD36/SR-B3, SR-B1, FPRL1, TLR2, and RAGE.

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2250-01
MW ~11.7 kDa
Storage/Handling Store desiccated at -20°C.
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2250-01-2 2 μg $ 76.00
2250-01-10 10 μg $ 112.00

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