Carbapenems

Carbapenems are a class of β-lactams with broad antibacterial activity. β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBPs are enzymes that catalyze a pentaglycine cross-link between alanine and lysine residues, providing additional strength to the cell wall. Without a pentaglycine cross-link, the integrity of the cell wall is severely compromised, and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Carbapenems are highly resistant to β-lactamases, and are commonly used as a last resort antibiotic of choice in the medical field due to their broad efficacy against both gram-positive and gram-negative bacteria and their poor oral bioavailabilility.
Showing 1-3 of 3 items.

Faropenem Sodium

Catalog ID Size Pricing
F-350-50 50 mg $ 239.00

Description

Faropenem sodium is an ultra broad-spectrum β-lactam of the penem antibiotic class. It has been shown to be β-lactamase resistant and is especially effective against anaerobic bacteria responsible for oral infections, but targets a variety of gram-positive and gram-negative bacteria. Faropenem sodium is freely soluble in water.

Product Specifications

Catalog ID F-350
CAS # 122547-49-3
MW 307.30 g/mol
Grade MOLECULAR BIOLOGY GRADE
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F-350-50 50 mg $ 239.00

Imipenem

Catalog ID Size Pricing
I-600-1 1 g $ 57.00
I-600-10 10 g $ 212.00
I-600-25 25 g $ 442.00
I-600-50 50 g $ 737.00

Description

Imipenem is a carbapenem β-lactam antibiotic with a broad target spectrum. It has been shown to be effective against ESBL-producing Enterobacteriaceae and gram-negative and gram-positive organisms. Imipenem has also been shown to be effective against bacteria from the genus Burkholderia. Resistance to imipenem is conferred through the loss of the OprD porin protein.

Product Specifications

Catalog ID I-600
CAS # 74431-23-5
MW 317.36 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at -20°C.
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I-600-1 1 g $ 57.00
I-600-10 10 g $ 212.00
I-600-25 25 g $ 442.00
I-600-50 50 g $ 737.00

Meropenem

Catalog ID Size Pricing
M-820-10 10 g $ 279.00
M-820-25 25 g $ 516.00
M-820-50 50 g $ 765.00
M-820-100 100 g $ 1,133.00

Description

Meropenem is a carbapenem β-lactam antibiotic. It targets gram-negative and gram-positive bacteria and displays high resistance to β-lactamase and kidney dehydropeptidase I activity. It is especially effective against bacteria responsible for causing meningitis and exhibits low toxicity when compared to similar antibiotics.

Product Specifications

Catalog ID M-820
CAS # 119478-56-7
MW 437.51 g/mol
Storage/Handling Store desiccated at -20°C.
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M-820-10 10 g $ 279.00
M-820-25 25 g $ 516.00
M-820-50 50 g $ 765.00
M-820-100 100 g $ 1,133.00

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