Chemokines

Chemokines are a family of small, inducible secreted cytokine proteins that are known for their conserved structural homology as well as their ability to mediate chemotaxis of various cells. They are essential for development and regulation of the immune system during both homeostasis and infection. Chemokines are usually divided into four subgroups based on the placement of conserved cysteine residues that are essential for tertiary structure. CC, CXC, CX3C, and XC chemokines refer to the number of amino acids separating the first two cysteine residues. GoldBio offers close to 100 different recombinant chemokines, which includes a variety of homeostatic and inflammatory chemokines from each subgroup.
Showing 1-20 of 99 items.

CCL1, Human

Catalog ID Size Pricing
2140-01-2 2 μg $ 76.00
2140-01-10 10 μg $ 112.00
2140-01-1000 1000 μg $ 1,437.00

Description

No description available

Product Specifications

Catalog ID 2140-01
MW ~8.6 kDa
Storage/Handling Store desiccated at -20°C.
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2140-01-2 2 μg $ 76.00
2140-01-10 10 μg $ 112.00
2140-01-1000 1000 μg $ 1,437.00

CCL11, Human

Catalog ID Size Pricing
2140-11-5 5 μg $ 76.00
2140-11-20 20 μg $ 112.00
2140-11-1000 1000 μg $ 1,437.00

Description

CCL11 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed in dermal fibroblasts. Expression of CCL11 is induced by IL1A and TNFA and inhibited by IFNG. It is strongly and selectively chemotactic for eosinophils and induces a calcium flux response in eosinophils; thus it is involved in a variety of eosinophilic inflammatory diseases. CCL11 is a ligand for CCR1, CCR2, CCR3, CCR5, and ACKR2 (D6).


GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2140-11
MW ~8.4 kDa
Storage/Handling Store desiccated at -20°C.
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2140-11-5 5 μg $ 76.00
2140-11-20 20 μg $ 112.00
2140-11-1000 1000 μg $ 1,437.00

CCL11, Murine

Catalog ID Size Pricing
2340-11-5 5 μg $ 76.00
2340-11-20 20 μg $ 112.00
2340-11-1000 1000 μg $ 1,437.00

Description

Murine CCL11 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed in fibroblasts, epithelial cells, smooth muscle cells, and dendritic cells. Expression of CCL11 is upregulated by several proinflammatory cytokines, including IL1A and TNFA, and is inhibited by IFNG. It is strongly and selectively chemotactic for eosinophils and induces a calcium flux response in eosinophils. CCL11 is involved in a variety of eosinophilic inflammatory diseases. CCL11 is a ligand primarily for CCR3, but also CCR1, CCR2, CCR5, and ACKR2 (D6).


GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2340-11
MW ~8.4 kDa
Storage/Handling Store desiccated at -20°C.
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2340-11-5 5 μg $ 76.00
2340-11-20 20 μg $ 112.00
2340-11-1000 1000 μg $ 1,437.00

CCL11, Rat

Catalog ID Size Pricing
2540-11-5 5 μg $ 76.00
2540-11-20 20 μg $ 112.00
2540-11-1000 1000 μg $ 1,437.00

Description

Rat CCL11 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed in fibroblasts, epithelial cells, smooth muscle cells, and dendritic cells. Expression of CCL11 is upregulated by several proinflammatory cytokines, including IL1A and TNFA, and is inhibited by IFNG. CCL11 is strongly and selectively chemotactic and activating for eosinophils and is involved in a variety of eosinophilic inflammatory diseases. It also plays a role in angiogenesis and tumor growth. CCL11 is a ligand primarily for CCR3, but also CCR1, CCR2, CCR5, and ACKR2 (D6).

Product Specifications

Catalog ID 2540-11
MW ~8.4 kDa
Storage/Handling Store desiccated at -20°C.
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2540-11-5 5 μg $ 76.00
2540-11-20 20 μg $ 112.00
2540-11-1000 1000 μg $ 1,437.00

CCL11, Rhesus Macaque

Catalog ID Size Pricing
2240-11-5 5 μg $ 76.00
2240-11-20 20 μg $ 112.00
2240-11-1000 1000 μg $ 1,437.00

Description

CCL11 is a chemokine containing four conserved cysteine residues, the first two of which are adjacent. It is expressed in dermal fibroblasts. Expression of CCL11 is induced by IL1A and TNFA and inhibited by IFNG. It is strongly and selectively chemotactic for eosinophils and induces a calcium flux response in eosinophils. CCL11 induces angiogenesis and endothelial cell sprouting from aortic rings in the absence of an eosinophil and has been implicated to be involved in a variety of eosinophilic inflammatory diseases. CCL11 is a ligand for CCR1, CCR2, CCR3, CCR5, and ACKR2 (D6).


GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2240-11
MW ~8.4 kDa
Storage/Handling Store desiccated at -20°C.
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2240-11-5 5 μg $ 76.00
2240-11-20 20 μg $ 112.00
2240-11-1000 1000 μg $ 1,437.00

CCL12, Murine

Catalog ID Size Pricing
2340-12-5 5 μg $ 76.00
2340-12-20 20 μg $ 112.00
2340-12-1000 1000 μg $ 1,437.00

Description

Murine CCL12 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed by macrophages and in lymph nodes and thymus tissue. Expression of CCL12 is upregulated after hypoxia and during bacterial infection and allergic inflammation. It is chemotactic for peripheral blood monocytes and fibrocytes and may play a critical role in the early stages of inflammation, as well as in joint and growth plate development. CCL12 is a ligand for CCR2.


GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2340-12
MW ~9.3 kDa
Storage/Handling Store desiccated at -20°C.
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2340-12-5 5 μg $ 76.00
2340-12-20 20 μg $ 112.00
2340-12-1000 1000 μg $ 1,437.00

CCL13, Human

Catalog ID Size Pricing
2140-13-5 5 μg $ 76.00
2140-13-20 20 μg $ 112.00
2140-13-1000 1000 μg $ 1,437.00

Description

CCL13 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed in epithelial cells and endothelial cells. Expression of CCL13 is induced by IL6 in primary synovial fibroblasts and activates the proliferation of rheumatoid synovial cells, contributing to the destruction of joints in rheumatoid arthritis. CCL13 is chemotactic for monocytes, T lymphocytes, and eosinophils. It stimulates histamine release from basophils and is a biomarker for asthma. CCL13 is a ligand for CCR2B, CCR3, and the viroceptor M3.


GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2140-13
MW ~8.6 kDa
Storage/Handling Store desiccated at -20°C.
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2140-13-5 5 μg $ 76.00
2140-13-20 20 μg $ 112.00
2140-13-1000 1000 μg $ 1,437.00

CCL14 (66 a.a.), Human

Catalog ID Size Pricing
2140-14A-2 2 μg $ 76.00
2140-14A-10 10 μg $ 112.00
2140-14A-1000 1000 μg $ 1,437.00

Description

CCL14 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed in plasma at high levels, and in spleen, liver, muscle, gut, and bone marrow tissue at lower levels. CCL14 causes a change in intracellular calcium levels and enzyme release in monocytes. It also enhances proliferation of myeloid progenitor cells that express CD34. CCL14 is a ligand for CCR1. This recombinant protein is N-terminally truncated CCL14 [9-74]. This natural variant causes a change in intracellular calcium levels in and is chemotactic for T-cells, monocytes, and eosinophils. It also inhibits HIV-1 isolates and is a ligand for CCR1, CCR3, and CCR5.


GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2140-14A
MW ~7.8 kDa
Storage/Handling Store desiccated at -20°C.
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2140-14A-2 2 μg $ 76.00
2140-14A-10 10 μg $ 112.00
2140-14A-1000 1000 μg $ 1,437.00

CCL14, Human

Catalog ID Size Pricing
2140-14-2 2 μg $ 76.00
2140-14-10 10 μg $ 112.00
2140-14-1000 1000 μg $ 1,437.00

Description

CCL14 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed in plasma at high levels, and in spleen, liver, muscle, gut, and bone marrow tissue at lower levels. CCL14 causes a change in intracellular calcium levels and enzyme release in monocytes. It also enhances proliferation of myeloid progenitor cells that express CD34. CCL14 is a ligand for CCR1. This recombinant protein is N-terminally truncated CCL14 [3-74].


GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2140-14
MW ~8.4 kDa
Storage/Handling Store desiccated at -20°C.
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2140-14-2 2 μg $ 76.00
2140-14-10 10 μg $ 112.00
2140-14-1000 1000 μg $ 1,437.00

CCL15 (68 a.a.), Human

Catalog ID Size Pricing
2140-15T-5 5 μg $ 76.00
2140-15T-25 25 μg $ 112.00
2140-15T-1000 1000 μg $ 1,437.00

Description

CCL15 is a chemokine containing six conserved cysteine residues that form three disulfide bonds essential for biological activity. It is often proteolytically processed in to smaller chains that are more potent as chemoattractants. CCL15 is expressed in liver, intestine, colon, and lung tissue. It is chemotactic for monocytes, T-lymphocytes, and eosinophils. CCL15 causes a change in intracellular calcium levels and a release of enzymes in monocytes. It is a ligand for CCR1, as well as CCR3 to an extent. This recombinant protein is N-terminally truncated CCL15 (25-92) and is 100-fold more potent as a chemoattractant than the non-truncated form. CCL15 (25-92) also plays a role in mediating angiogenesis.

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2140-15T
MW ~7.4 kDa
Storage/Handling Store desiccated at -20°C.
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2140-15T-5 5 μg $ 76.00
2140-15T-25 25 μg $ 112.00
2140-15T-1000 1000 μg $ 1,437.00

CCL15, Human

Catalog ID Size Pricing
2140-15-5 5 μg $ 76.00
2140-15-25 25 μg $ 112.00
2140-15-1000 1000 μg $ 1,437.00

Description

CCL15 is a chemokine containing six conserved cysteine residues that form three disulfide bonds essential for biological activity. It is often proteolytically processed in to smaller chains that are more potent as chemoattractants. CCL15 is expressed in liver, intestine, colon, and lung tissue. It is chemotactic for monocytes, T-lymphocytes, and eosinophils. CCL15 causes a change in intracellular calcium levels and a release of enzymes in monocytes. It is a ligand for CCR1, as well as CCR3 to an extent. CCL15 is most similar in sequence to CCL23.


GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2140-15
MW ~10.2 kDa
Storage/Handling Store desiccated at -20°C.
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2140-15-5 5 μg $ 76.00
2140-15-25 25 μg $ 112.00
2140-15-1000 1000 μg $ 1,437.00

CCL16, Human

There is no image for CCL16, Human CCL16, Human
Catalog ID Size Pricing
2140-16-5 5 μg $ 76.00
2140-16-20 20 μg $ 112.00
2140-16-1000 1000 μg $ 1,437.00

Description

CCL16 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed at highest levels in liver tissue and monocytes, and at lower levels in spleen, thymus, and some lymphocytes. Expression of CCL16 is induced by IFNG, LPS, and IL10. It is chemotactic for peripheral blood mononuclear cells, induces a change in intracellular calcium levels of monocytes, and inhibits proliferation of myeloid progenitor cells. It is a weak ligand for CCR1, CCR2, CCR5, CCR8, and histamine receptor H4.

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2140-16
MW ~11.2 kDa
Storage/Handling Store desiccated at -20°C.
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2140-16-5 5 μg $ 76.00
2140-16-20 20 μg $ 112.00
2140-16-1000 1000 μg $ 1,437.00

CCL17, Human

Catalog ID Size Pricing
2140-17-5 5 μg $ 76.00
2140-17-20 20 μg $ 112.00
2140-17-1000 1000 μg $ 1,437.00

Description

CCL17 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed constitutively in the thymus and lymph nodes and transiently in peripheral blood mononuclear cells that have been induced by phytogemagglutinin. It is chemotactic for T-cells and plays a role in T-cell development, trafficking, and activation. CCL17 is a ligand for CCR4, CCR8, and the erythrocyte receptor ACKR1.


GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2140-17
MW ~8.1 kDa
Storage/Handling Store desiccated at -20°C.
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2140-17-5 5 μg $ 76.00
2140-17-20 20 μg $ 112.00
2140-17-1000 1000 μg $ 1,437.00

CCL17, Murine

Catalog ID Size Pricing
2340-17-5 5 μg $ 76.00
2340-17-20 20 μg $ 112.00
2340-17-100 100 μg $ 324.00
2340-17-250 250 μg $ 580.00
2340-17-500 500 μg $ 900.00
2340-17-1000 1000 μg $ 1,437.00

Description

CCL17 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed constitutively in the thymus and lymph nodes and transiently in peripheral blood mononuclear cells that have been induced by phytogemagglutinin. It is chemotactic for T-cells and plays a role in T-cell development trafficking, and activation. CCL17 promotes atherosclerosis by restricting the maintenance of regulatory T-cells, thereby limiting their expansion. It is a ligand for CCR4, CCR8, and the erythrocyte receptor ACKR1.

Product Specifications

Catalog ID 2340-17
MW ~7.9 kDa
Storage/Handling Store desiccated at -20°C.
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2340-17-5 5 μg $ 76.00
2340-17-20 20 μg $ 112.00
2340-17-100 100 μg $ 324.00
2340-17-250 250 μg $ 580.00
2340-17-500 500 μg $ 900.00
2340-17-1000 1000 μg $ 1,437.00

CCL17, Rat

Catalog ID Size Pricing
2540-17-5 5 μg $ 76.00
2540-17-20 20 μg $ 112.00
2540-17-1000 1000 μg $ 1,437.00

Description

Rat CCL17 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed constitutively in the thymus and lymph nodes and transiently in peripheral blood mononuclear cells that have been induced by phytogemagglutinin. CCL17 is chemotactic for T-cells and plays a role in T-cell development, trafficking, and activation. It promotes atherosclerosis by regulating homeostasis of regulatory T-cells, thereby limiting their expansion. CCL17 is a ligand for CCR4, CCR8, and the erythrocyte receptor ACKR1.

Product Specifications

Catalog ID 2540-17
MW ~8.1 kDa
Storage/Handling Store desiccated at -20°C.
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2540-17-5 5 μg $ 76.00
2540-17-20 20 μg $ 112.00
2540-17-1000 1000 μg $ 1,437.00

CCL18, Human

Catalog ID Size Pricing
2140-18-2 2 μg $ 76.00
2140-18-10 10 μg $ 112.00
2140-18-1000 1000 μg $ 1,437.00

Description

CCL18 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed constitutively in lung tissues and transiently in alveolar macrophages and follicular dendritic cells induced by IL4, IL10, IL13, LPS, or PMA. Expression of CCL18 is inhibited by IFNG. CCL18 is chemotactic for activated T-lymphocytes, non-activated lymphocytes, and basophils and likely plays a role in initiation of immune responses. It is a ligand for CCR8 and GPER1.

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2140-18
MW ~7.9 kDa
Storage/Handling Store desiccated at -20°C.
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2140-18-2 2 μg $ 76.00
2140-18-10 10 μg $ 112.00
2140-18-1000 1000 μg $ 1,437.00

CCL19, Murine

There is no image for CCL19, Murine CCL19, Murine
Catalog ID Size Pricing
2340-19-5 5 μg $ 76.00
2340-19-20 20 μg $ 112.00
2340-19-1000 1000 μg $ 1,437.00

Description

CCL19 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed by dendritic cells in lymph nodes, as well as in spleen and thymus tissue. Expression of CCL19 is upregulated by IFNG and TNF-alpha. CCL19 has shown to be chemotactic for T-cells and B-cells, as well as CFU granulocyte macrophages. It plays a role in mobilization of dendritic cells from the epidermis to lymph nodes and development of local lymphoid tissues. CCL19 is a ligand for CCR7 (EBI1), as well as the atypical chemokine receptors CCRL1 and CCRL2.

Product Specifications

Catalog ID 2340-19
MW ~9.2 kDa
Storage/Handling Store desiccated at -20°C.
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2340-19-5 5 μg $ 76.00
2340-19-20 20 μg $ 112.00
2340-19-1000 1000 μg $ 1,437.00

CCL2, Human

Catalog ID Size Pricing
2140-02-5 5 μg $ 76.00
2140-02-20 20 μg $ 112.00
2140-02-100 100 μg $ 324.00
2140-02-250 250 μg $ 580.00
2140-02-500 500 μg $ 900.00
2140-02-1000 1000 μg $ 1,437.00

Description

CCL2 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed by monocytes, vascular endothelial cells, smooth muscle cells, glomerular mesangial cells, osteoblastic cells, and human pulmonary type 2-like epithelial cells. CCl2 expression is induced in peripheral blood mononuclear leukocytes by PHA, LPS, and IL1. It is chemotactic for monocytes and basophils and plays a role in recruiting macrophages and perpetuating inflammation in the joints of patients with rheumatoid arthritis. CCl2 is inhibited by insulin’s inhibitory effect on the activity of transcription factor NF-kappa-B. CCl2 is a ligand for CCR2 and CCR4.


GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2140-02
MW ~8.7 kDa
Storage/Handling Store desiccated at -20°C.
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2140-02-5 5 μg $ 76.00
2140-02-20 20 μg $ 112.00
2140-02-100 100 μg $ 324.00
2140-02-250 250 μg $ 580.00
2140-02-500 500 μg $ 900.00
2140-02-1000 1000 μg $ 1,437.00

CCL20, Human

Catalog ID Size Pricing
2140-20-5 5 μg $ 76.00
2140-20-20 20 μg $ 112.00
2140-20-1000 1000 μg $ 1,437.00

Description

CCL20 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed in the liver as well as in lymphocytes, monocytes, and leukemia cells that have been induced by a mediator of inflammation, such as IFNG, IL1B, LPS, or PMA. It is upregulated in psoriasis because of proinflammatory mediators produced in the skin and attracts T lymphocytes to lesions. CCL20 is chemotactic mainly for lymphocytes, but also for granulocytes and immature dendritic cells. It is a ligand for CCR6.


GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2140-20
MW ~8.0 kDa
Storage/Handling Store desiccated at -20°C.
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2140-20-5 5 μg $ 76.00
2140-20-20 20 μg $ 112.00
2140-20-1000 1000 μg $ 1,437.00

CCL20, Murine

Catalog ID Size Pricing
2340-20-5 5 μg $ 76.00
2340-20-20 20 μg $ 112.00
2340-20-100 100 μg $ 324.00
2340-20-250 250 μg $ 580.00
2340-20-500 500 μg $ 900.00
2340-20-1000 1000 μg $ 1,437.00

Description

CCL20 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed in the liver as well as in lymphocytes, monocytes, and leukemia cells that have been induced by a mediator of inflammation, such as IFNG, IL1B, LPS, or PMA. It is upregulated in psoriasis because of proinflammatory mediators produced in the skin and attracts T lymphocytes to lesions. CCL20 is chemotactic mainly for lymphocytes, but also for granulocytes and immature dendritic cells and it plays a role in development of mucosal lymphoid tissue. It is a ligand for CCR6.

Product Specifications

Catalog ID 2340-20
MW ~8.0 kDa
Storage/Handling Store desiccated at -20°C.
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2340-20-5 5 μg $ 76.00
2340-20-20 20 μg $ 112.00
2340-20-100 100 μg $ 324.00
2340-20-250 250 μg $ 580.00
2340-20-500 500 μg $ 900.00
2340-20-1000 1000 μg $ 1,437.00

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