F_Products

FGF9 is a member of the Fibroblast Growth Factor family of proteins. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF9 targets glial cells, astrocytes and other cells that express FGFR 1c, 2c, 3b, 3c and 4. FGF9 is a potent mitogen for both prostatic epithelial and stromal cells in culture and is an abundant, secreted growth factor that can act as both a paracrine mitogen for epithelial cells and as an autocrine mitogen for stromal cells. There is a 99% amino acid sequence homology between human, mouse and rat FGF9 proteins. In the FGF family, FGF9 is most closely associated with FGF16 and FGF20 (see additional information).

FGF9 is a member of the Fibroblast Growth Factor family of proteins. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF9 targets glial cells, astrocytes and other cells that express FGFR 1c, 2c, 3b, 3c and 4. FGF9 is a potent mitogen for both prostatic epithelial and stromal cells in culture and is an abundant, secreted growth factor that can act as both a paracrine mitogen for epithelial cells and as an autocrine mitogen for stromal cells. There is a 99% amino acid sequence homology between human, mouse and rat FGF9 proteins. In the FGF family, FGF9 is most closely associated with FGF16 and FGF20 (see additional information).

Fipronil is a phenylpyrazole derivative that is used as an insecticide in agriculture for its neurotoxic effects. It is researched for environmental impact on aquatic and non-pest insect communities. Fipronil has been shown to have neurotoxic effects by inhibiting γ-aminobutyric acid (GABA) receptors on chloride channels. Inhibition of these channels hyperstimulates neurons and results with insect death. It has also been shown that fipronil has a high affinity for invertebrate GABA receptors and low affinity for vertebrate receptors.

Florfenicol, like chloramphenicol, is a bacteriostatic antibiotic and an analog of thiamphenicol. It targets gram-negative and gram-positive bacteria, especially those responsible for bovine respiratory infections. Florfenicol is soluble in water and lipid solvents.

FLT3LG is a hematopoietic cytokine whose activities are mediated by binding to the transmembrane glycoprotein Flt3. Flt3 was first discovered as a member of the class III subfamily of receptor tyrosine kinases (RTK) whose expression among hematopoietic cells was found to be restricted to highly enriched stem/progenitor cell populations. Additionally, class III RTKs include the receptors from SCF, CSF3 and PDGF. Not surprisingly, FLT3LG is also structurally related to CSF3 and SCF. All three cytokines have been shown to exist both as type I transmembrane proteins and as soluble proteins. The predominant human FLT3LG isoform is a transmembrane protein that can undergo proteolytic cleavage to generate a soluble form of the protein. An alternatively-spliced FLT3LG mRNA, encoding a soluble form of the human FLT3LG, has also been identified. FLT3LG is widely expressed in various human and mouse tissues. At the amino acid sequence level, human and mouse FLT3LG are approximately 72% identical and the two proteins exhibit cross-species activity. FLT3LG has been shown to synergize with a wide variety of hematopoietic cytokines to stimulate the growth and differentiation of early hematopoietic progenitors.

Flubendazole is a benzimidazole compound that is used as an antiparasitic and anti-cancer agent. It has been shown to be an effective anthelminthic chemical by inhibiting tubulin synthesis and disrupting cytoskeleton formation. Flubendazole has also been shown in vivo to be a strong anti-cancer compound by the same mechanism and is potent toward vinblastine resistant cell lines.

Tubulin is vital protein component that provides the structural shape of cells as well as being integral to replication. Halting tubulin formation ruins the structural integrity and dysregulates cytosolic equilibrium. Tubulin inhibition also effects the subfamilies α-tubulin and β-tubulin which facilitate chromosomal migration during cellular replication.

Flucloxacillin sodium is a narrow-spectrum penicillin antibiotic similar to cloxacillin. Resistant to β-lactamases, it targets gram-positive organisms such as Staphylococcus aureus. It can causes cholestatic liver damage.

Fluconazole is a fungistatic triazole antifungal targeting ergosterol synthesis leading to increased permeability of the fungal cell membrane. It is effective against Candida species, Cryptococcus species, neoformans, and dermatophytes. Fluconazole has been shown to down-regulate the metallothionein gene and inhibit CYP2C19, CYP2C9, and CYP3A4.

Flumequine is a first generation fluoroquinolone antibiotic targeting gram-negative bacteria, especially those responsible for enteric infections in animals. It is freely soluble in alkali hydroxide solutions of dilute concentrations.

Flumethasone is a glucocorticoid used as an anti-inflammatory for a variety of animals. It is commonly investigated for its effectiveness in animals to combat inflammatory symptoms caused by pathogens and to better understand inflammatory mechanisms. It is also used as to investigate novel techniques that detect and quantify steroid compounds within muscles.

Flumethasone has been shown to exert anti-inflammtory effects by functioning as a glucocorticoid receptor agonist. Stimulating this receptor promotes inhibition of phospholipase A2 activity. This enzyme catalyzes arachidonic acid into eicosanoids most of which stimulate anti-inflammation mechanisms.

Fluoresceinamine Isomer I is a fluorescent molecule used for staining procedures. For tissue staining it was combined with albumin to form a useful stain for tissues of malignant brain tumors. Fluoresceinamine Isomer I is also used as a label for detection of synthesis of DNA in vivo and labeling of other nucleosides, nucleotides and oligonucleotides.

Flurbiprofen is a phenylalkanoic acid that is part of the non-steroid anti-inflammatory family. It is used as a cyclooxygenase (COX) inhibitor, diminishing metabolites that activate inflammatory responses.

Flurbiprofen strongly inhibits two forms of the human COX enzyme: COX-1 and COX-2. Both enzymes catalyze the reaction of prostaglandin synthesis from arachidonic acid. COX-1 however has been found to influence other physiological processes such as mucus and acid secretion in the stomach.

Flurbiprofen sodium is the salt form of a phenylalkanoic acid that is part of the non-steroid anti-inflammatory drug (NSAID) family. It functions as a cyclooxygenase (COX) inhibitor and as an antimiotic. Flurbiprofen sodium has also been used to investigate in vivo novel drug delivery systems.

Flurbiprofen sodium strongly inhibits two forms of the human COX enzyme: COX-1 and COX-2. Both enzymes catalyze the synthesis of prostaglandin, a pro-inflammatory lipid, from arachidonic acid. COX-1 however has been found to influence other physiological processes such as mucus and acid secretion in the stomach. Antimiotic effects observed with flurbiprofen sodium use is due to decreased prostaglandin levels.

This stainless steel pair of forceps has a length of 23 cm, and has been developed for the handling of plantlets in Plant Tissue culture. The risk of contamination is lowered because of the long, thin extended legs, which increases the distance between the researcher's hand and the sterile plantlets and culture vessel. The long thin legs of this pair of forceps allows easy maneuvering in long narrow culture tubes and the bottom of the tube can be reached without contacting the sterile rim of the tubes. The forceps are also light and require only slight pressure to close, thereby giving the forceps a fine ergonomic performance without fatiguing the hand.

Stainless Steel rest for holding sterile forceps and scalpel handles in a convenient position.

Formononetin is an isoflavonoid phytoestrogen that is used in microbiology and oncology research as a vasodilator, anti-viral, anti-inflammatory and anti-cancer agent. It has also been used as an anti-parasitic compound against Giardia lamblia trophozoites however, the mechanism of action is not well understood.

Fosfomycin sodium is a phosphoenolpyruvate analog antibiotic isolated from Streptomyces fradiae. It targets gram-positive and gram-negative bacteria, especially E. faecalis and E. coli. Fosfomycin concentrates in the bladder and kidney, decreasing nephrotoxicity and ototoxicity of anti-tumor agents containing platinum.

Fraxetin is a phenolic antioxidant. It has been used to protect against rotenone-induced apoptosis in neuroblastoma cells. Fraxetin also possesses antitumor and antimetastatic properties on M2 macrophage differentiation.

Furazolidone is a nitrofuran derivative antibiotic with antiprotozoal and antibacterial activity. It targets a wide variety of bacteria, including those responsible for gastrointestinal infections. It has also been used as a DNA cross-linking agent.

Furazolidone binds bacterial DNA, inhibiting monoamine oxidase (MAO). It induces cross-links leading to an increased rate of mutation or halted DNA replication.