Macrolides

Macrolides are protein synthesis inhibitors that prevent peptidyltransferase from adding the growing peptide attached to tRNA to the next amino acid. Macrolides are also known to inhibit ribosomal translocation and dissociate the peptidyl-tRNA from the ribosome. Macrolides bind reversibly to the P site of the 50S subunit of the bacterial ribosome in a bacteriostatic function. Macrolides, such as erythromycin, clarithromycin, and roxithromycin, have proven to be an effective long-term treatment for the idiopathic, Asian-prevalent lung disease diffuse panbronchiolitis (DPB). Macrolides have been successful in treating DPB through immunomodulation and have low-dose requirements.
Showing 1-11 of 11 items.

Azithromycin Dihydrate

Catalog ID Size Pricing
A-900-25 25 mg $ 229.00

Description

Azithromycin is a broad-spectrum macrolide antibiotic similar in structure to erythromycin. It is effective against various gram-negative and gram-positive bacteria. It has also displayed efficacy against certain Mycoplasma species. Azithromycin also exhibits anti-inflammatory and immunosuppressive properties. Azithromycin dihydrate is slightly soluble in aqueous solution.

Macrolide antibiotics are composed of a macrocyclic lactone ring attached to one or more deoxy sugars. They inhibit bacterial protein synthesis by irreversibly binding the P site of the 50s ribosome, preventing peptide bond formation and translocation.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications

Catalog ID A-900
CAS # 117772-70-0
MW 785.01 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C.
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A-900-25 25 mg $ 229.00

Clarithromycin

Catalog ID Size Pricing
C-880-100 100 mg $ 63.00
C-880-250 250 mg $ 104.00
C-880-1 1 g $ 317.00

Description

Clarithromycin is a macrolide antibiotic and is an acid-stable form of erythromycin. It is effective against gram-negative and gram-positive bacteria. Clarithromycin has been used to research cardiac transplant rejection and COPD inflammation markers. It is also an inhibitor and substrate for CYP3A4.

Product Specifications

Catalog ID C-880
CAS # 81103-11-9
MW 747.95 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store desiccated at 4°C. Protect from oxidizing agents.
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C-880-100 100 mg $ 63.00
C-880-250 250 mg $ 104.00
C-880-1 1 g $ 317.00

Dirithromycin

Catalog ID Size Pricing
D-305-1 1 g $ 116.00

Description

No description available

Product Specifications

Catalog ID D-305
CAS # 62013-04-1
MW 835.07 g/mol
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D-305-1 1 g $ 116.00

Erythromycin

Catalog ID Size Pricing
E-350-5 5 g $ 24.00
E-350-100 100 g $ 90.00
E-350-250 250 g $ 191.00
E-350-500 500 g $ 350.00

Description

Erythromycin is a macrolide antibiotic isolated from Streptomyces erythreus. It displays strong efficacy against gram-positive cocci and bacilli and some mycobacteria, mycoplasma, and spirochetes. In addition to its antimicrobial properties, erythromycin is a motilin receptor agonist that has been shown to inhibit respiratory glycoconjugate secretion in vitro. It has also been used to select for recombinant Lactococcus lactis MG1363 strains in microbiological applications.

Product Specifications

Catalog ID E-350
CAS # 114-07-8
MW 733.93 g/mol
Storage/Handling Store at 4°C.
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E-350-5 5 g $ 24.00
E-350-100 100 g $ 90.00
E-350-250 250 g $ 191.00
E-350-500 500 g $ 350.00

Erythromycin Estolate

Catalog ID Size Pricing
E-300-5 5 g $ 105.00

Description

Erythromycin is a macrolide antibiotic isolated from Streptomyces erythreus. It displays strong efficacy against gram-positive cocci and bacilli and some mycobacteria, mycoplasma, and spirochetes. In addition to its antimicrobial properties, erythromycin is a motilin receptor agonist that has been shown to inhibit respiratory glycoconjugate secretion in vitro. Erythromycin estolate is freely soluble in organic solvents.

Product Specifications

Catalog ID E-300
CAS # 3521-62-8
MW 1056.39 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C.
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E-300-5 5 g $ 105.00

Erythromycin Ethylsuccinate

Catalog ID Size Pricing
E-301-25 25 g $ 195.00

Description

Erythromycin ethylsuccinate is a macrolide antibiotic with a target spectrum similar to that of penicillin. It has shown high efficacy against Mycoplasma pneumoniae and Legionella pneumophila. Additionally, it has been used to study erythromycin-resistance bacteria, down-regulation of motilin receptors, and mutations on the omsA and firA genes. Erythromycin ethylsuccinate is freely soluble in organic solvents.

Product Specifications

Catalog ID E-301
CAS # 1264-62-6
MW 862.05 g/mol
Grade MOLECULAR BIOLOGY GRADE
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E-301-25 25 g $ 195.00

Rapamycin

Catalog ID Size Pricing
R-101-100 100 mg $ 229.00
R-101-500 500 mg $ 899.00

Description

Rapamycin is a macrolide antibiotic isolated from Streptomyces hygroscopicus. It has been shown to display anticancer activity such as induction of apoptosis and inhibition of angiogenesis and proliferation in tumor cell lines. Rapamycin is also an immunosuppressant and FRAP inhibitor and inhibits lymphokine-induced cell proliferation.

Product Specifications

Catalog ID R-101
CAS # 53123-88-9
MW 914.17 g/mol
Storage/Handling Store at room temperature.
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R-101-100 100 mg $ 229.00
R-101-500 500 mg $ 899.00

Roxithromycin

Catalog ID Size Pricing
R-500-5 5 g $ 57.00
R-500-10 10 g $ 104.00

Description

Roxithromycin is a macrolide antibiotic and derivative of erythromycin. It targets both gram-negative and gram-positive bacteria and has shown strong efficacy against Legionella pneumophila and a variety of oral pathogens. Additionally, roxithromycin inhibits the activation of NADPH oxidase and promotes neutrophil apoptosis.

Product Specifications

Catalog ID R-500
CAS # 80214-83-1
MW 837.05 g/mol
Grade MOLECULAR BIOLOGY GRADE
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R-500-5 5 g $ 57.00
R-500-10 10 g $ 104.00

Spiramycin

Catalog ID Size Pricing
S-470-1 1 g $ 72.00
S-470-5 5 g $ 252.00

Description

Spiramycin is a broad-spectrum macrolide antibiotic effective against gram-negative and gram-positive bacteria as well as some Toxoplasma parasites. Spiramycin is a mixture of spiramycin I, II, and III and has been used to study sepsis in mice.

Product Specifications

Catalog ID S-470
CAS # 8025-81-8
MW 843.05 g/mol
Grade MOLECULAR BIOLOGY GRADE
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S-470-1 1 g $ 72.00
S-470-5 5 g $ 252.00

Tilmicosin

Catalog ID Size Pricing
T-330-100 100 mg $ 82.00

Description

Tilmicosin is a macrolide antibiotic structurally similar to tylosin. It targets gram-negative bacteria, especially those responsible for bovine respiratory infections.

Product Specifications

Catalog ID T-330
CAS # 108050-54-0
MW 869.13 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C.
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T-330-100 100 mg $ 82.00

Tylosin Tartrate

Catalog ID Size Pricing
T-550-1 1 g $ 52.00
T-550-5 5 g $ 162.00
T-550-10 10 g $ 264.00

Description

Tylosin tartrate is a macrolide antibiotic isolated from Streptomyces fradiae. It is a mixture of tylosin A, B, C, and D tartrates effective against gram-positive bacteria and Mycoplasma species. It has been used to study protein synthesis, abscess prevention in cattle, and Mycoplasma infections.

Product Specifications

Catalog ID T-550
CAS # 74610-55-2
MW 1066.19 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C.
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T-550-1 1 g $ 52.00
T-550-5 5 g $ 162.00
T-550-10 10 g $ 264.00

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