Neurotrophic Factors

Neurotrophic factors are involved in many roles of the central nervous system beyond growth and development. They are responsible for the maintenance and survival of neurons and have been the subject of extensive research. There is continued interest in the research of potential neurotrohpic factor therapies, which may help treat Alzheimer’s disease, Parkinson’s disease and other neurodegenerative disorders. GoldBio offers high-quality recombinant neurotropic factors for research purposes, but at a more affordable price.
Showing 1-20 of 24 items.

CDNF, Murine

Catalog ID Size Pricing
1370-16-5 5 μg $ 76.00
1370-16-25 25 μg $ 112.00
1370-16-1000 1000 μg $ 1,437.00

Description

CDNF is a secreted neurotrophic factor that contains 8 conserved cysteine residues, much like its relative MANF. CDNF and its structural homolog MANF each contain an N-terminal saposin-like lipid binding domain and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF is expressed in several tissues, including the embryonic and postnatal brains of mice, as well as the heart, skeletal muscle, and testis. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and MANF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease.

Product Specifications

Catalog ID 1370-16
MW ~18.5 kDa
Storage/Handling Store desiccated at -20°C.
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1370-16-5 5 μg $ 76.00
1370-16-25 25 μg $ 112.00
1370-16-1000 1000 μg $ 1,437.00

CDNF, Rat

Catalog ID Size Pricing
1570-16-5 5 μg $ 76.00
1570-16-25 25 μg $ 112.00
1570-16-1000 1000 μg $ 1,437.00

Description

CDNF is a secreted neurotrophic factor that contains 8 conserved cysteine residues, much like its relative MANF. CDNF and its structural homolog MANF each contain an N-terminal saposin-like lipid binding domain and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF is expressed in several tissues, including the embryonic and postnatal brains of mice, as well as the heart, skeletal muscle, and testis. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and MANF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease.

Product Specifications

Catalog ID 1570-16
MW ~18.8 kDa
Storage/Handling Store desiccated at -20°C.
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1570-16-5 5 μg $ 76.00
1570-16-25 25 μg $ 112.00
1570-16-1000 1000 μg $ 1,437.00

CNTF, Human

Catalog ID Size Pricing
1170-08-5 5 μg $ 76.00
1170-08-20 20 μg $ 112.00
1170-08-1000 1000 μg $ 1,437.00

Description

Ciliary neurotrophic factor (CNTF) is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. It was initially identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture. The protein is also a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. In addition, CNTF is useful for treatment of motor neuron disease and it could reduce food intake without causing hunger or stress. CNTF is structurally related to IL6, IL11, LIF, and OSM. All of these four helix bundle cytokines share gp130 as a signal-transducing subunit in their receptor complexes.

Product Specifications

Catalog ID 1170-08
MW ~22.9 kDa
Storage/Handling Store desiccated at -20°C.
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1170-08-5 5 μg $ 76.00
1170-08-20 20 μg $ 112.00
1170-08-1000 1000 μg $ 1,437.00

CNTF, Murine

Catalog ID Size Pricing
1370-08-5 5 μg $ 76.00
1370-08-25 25 μg $ 112.00
1370-08-100 100 μg $ 324.00
1370-08-250 250 μg $ 580.00
1370-08-500 500 μg $ 900.00
1370-08-1000 1000 μg $ 1,437.00

Description

Ciliary neurotrophic factor (CNTF) is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. It was initially identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture. The protein is also a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. In addition, CNTF is useful for treatment of motor neuron disease and it could reduce food intake without causing hunger or stress. CNTF is structurally related to IL6, IL11, LIF, and OSM. All of these four helix bundle cytokines share gp130 as a signal-transducing subunit in their receptor complexes.

Product Specifications

Catalog ID 1370-08
MW ~22.5 kDa
Storage/Handling Store desiccated at -20°C.
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1370-08-5 5 μg $ 76.00
1370-08-25 25 μg $ 112.00
1370-08-100 100 μg $ 324.00
1370-08-250 250 μg $ 580.00
1370-08-500 500 μg $ 900.00
1370-08-1000 1000 μg $ 1,437.00

CNTF, Rat

Catalog ID Size Pricing
1570-08-5 5 μg $ 76.00
1570-08-25 25 μg $ 112.00
1570-08-100 100 μg $ 324.00
1570-08-250 250 μg $ 580.00
1570-08-500 500 μg $ 900.00
1570-08-1000 1000 μg $ 1,437.00

Description

Ciliary neurotrophic factor (CNTF) is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. It was initially identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture. The protein is also a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. In addition, CNTF is useful for treatment of motor neuron disease and it could reduce food intake without causing hunger or stress. CNTF is structurally related to IL6, IL11, LIF, and OSM. All of these four helix bundle cytokines share gp130 as a signal-transducing subunit in their receptor complexes.

Product Specifications

Catalog ID 1570-08
MW ~22.7 kDa
Storage/Handling Store desiccated at -20°C.
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1570-08-5 5 μg $ 76.00
1570-08-25 25 μg $ 112.00
1570-08-100 100 μg $ 324.00
1570-08-250 250 μg $ 580.00
1570-08-500 500 μg $ 900.00
1570-08-1000 1000 μg $ 1,437.00

FAM19A2, Human

There is no image for FAM19A2, Human FAM19A2, Human
Catalog ID Size Pricing
2150-01-5 5 μg $ 76.00
2150-01-20 20 μg $ 112.00
2150-01-1000 1000 μg $ 1,437.00

Description

FAM19A2 (TAFA-2) is chemokine-like protein containing ten cysteine residues that are conserved amongst the FAM19A (TAFA) family. This family of proteins was first identified by using a clustering algorithm on uncharacterized cDNA sequences and found to be distantly related to C-C motif chemokines, such as CCL3. FAM19A2 is expressed predominantly in the CNS, with very low expression levels detected in colon and spleen. Expression levels of FAM19A2 are highest in the occipital and frontal cortex and it is believed to be expressed constitutively. FAM19A2 is hypothesized to function as a brain-specific chemokine that regulates immune response in the CNS, as a neurokine that modulates immune response, or as a control of axonal sprouting following brain injury.


GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Product Specifications

Catalog ID 2150-01
MW ~11.2 kDa
Storage/Handling Store desiccated at -20°C.
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2150-01-5 5 μg $ 76.00
2150-01-20 20 μg $ 112.00
2150-01-1000 1000 μg $ 1,437.00

GDNF, Human

Catalog ID Size Pricing
1170-14-2 2 μg $ 76.00
1170-14-10 10 μg $ 112.00
1170-14-100 100 μg $ 574.00
1170-14-250 250 μg $ 904.00
1170-14-500 500 μg $ 1,483.00
1170-14-1000 1000 μg $ 2,343.00

Description

Glial cell-derived neurotrophic factor (GDNF) is a small protein that promotes the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. GDNF is a founding member of the GDNF family of ligands (GFL) and has been shown to interact with GFRA2 and GDNF family receptor alpha 1. GDNF (monomer) contains seven conserved cysteine residues, one of which (Cys 101) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cystine knot configuration.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Product Specifications

Catalog ID 1170-14
MW ~15.2 kDa
Storage/Handling Store desiccated at -20°C.
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1170-14-2 2 μg $ 76.00
1170-14-10 10 μg $ 112.00
1170-14-100 100 μg $ 574.00
1170-14-250 250 μg $ 904.00
1170-14-500 500 μg $ 1,483.00
1170-14-1000 1000 μg $ 2,343.00

GDNF, Rat

Catalog ID Size Pricing
1570-14-2 2 μg $ 76.00
1570-14-10 10 μg $ 112.00
1570-14-100 100 μg $ 574.00
1570-14-250 250 μg $ 904.00
1570-14-500 500 μg $ 1,483.00
1570-14-1000 1000 μg $ 2,343.00

Description

Glial cell-derived neurotrophic factor (GDNF) is a small protein that promotes the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. GDNF is a founding member of the GDNF family of ligands (GFL) and has been shown to interact with GDNF family receptor alpha 1 (GDNFA1) and GDNFA2. Rat GDNF exists as a homodimer and contains seven conserved cysteine residues, one of which (Cys 101) is used for inter-chain disulfide bridging while the others are involved in intramolecular ring formation known as the cystine knot configuration.

Product Specifications

Catalog ID 1570-14
MW ~29.8 kDa
Storage/Handling Store desiccated at -20°C.
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1570-14-2 2 μg $ 76.00
1570-14-10 10 μg $ 112.00
1570-14-100 100 μg $ 574.00
1570-14-250 250 μg $ 904.00
1570-14-500 500 μg $ 1,483.00
1570-14-1000 1000 μg $ 2,343.00

GMFB, Human

Catalog ID Size Pricing
1170-07-2 2 μg $ 76.00
1170-07-10 10 μg $ 112.00
1170-07-1000 1000 μg $ 2,343.00

Description

Glia maturation factor beta is an actin-binding protein that shows sequence similarity to the ADF/ cofilin family. It is expressed in the cytosol and on the cell surface of astrocytes and interacts with target receptors in a juxtacrine manner. GMFB is involved in the differentiation of glial cells and neurons. It stimulates axon regeneration and proliferation of astroblasts, and inhibits proliferation of tumors. It also reversibly inhibits proliferation of neuronal and non-neuronal neoplastic cells by arresting the cell cycle in the G0/G1 phase. It is suggested that GMFB acts an intracellular regulator of signal pathways.

Product Specifications

Catalog ID 1170-07
MW ~16.6 kDa
Storage/Handling Store desiccated at -20°C.
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1170-07-2 2 μg $ 76.00
1170-07-10 10 μg $ 112.00
1170-07-1000 1000 μg $ 2,343.00

GMFB, Murine

Catalog ID Size Pricing
1370-07-2 2 μg $ 76.00
1370-07-10 10 μg $ 112.00
1370-07-1000 1000 μg $ 1,795.00

Description

Glia maturation factor beta is an actin-binding protein that shows sequence similarity to the ADF/ cofilin family. It is expressed in the cytosol and on the cell surface of astrocytes and interacts with target receptors in a juxtacrine manner. GMFB is involved in the differentiation of glial cells and neurons. It stimulates axon regeneration and proliferation of astroblasts, and inhibits proliferation of tumors. It also reversibly inhibits proliferation of neuronal and non-neuronal neoplastic cells by arresting the cell cycle in the G0/G1 phase. It is suggested that GMFB acts an intracellular regulator of signal pathways. Analysis of crystallography and NMR reveals structural differences between murine and human ADF-H domains.

Product Specifications

Catalog ID 1370-07
MW ~16.6 kDa
Storage/Handling Store desiccated at -20°C.
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1370-07-2 2 μg $ 76.00
1370-07-10 10 μg $ 112.00
1370-07-1000 1000 μg $ 1,795.00

GMFB, Rat

Catalog ID Size Pricing
1570-07-2 2 μg $ 76.00
1570-07-10 10 μg $ 112.00
1570-07-1000 1000 μg $ 1,795.00

Description

Glia maturation factor beta is an actin-binding protein that shows sequence similarity to the ADF/ cofilin family. It is expressed in the cytosol and on the cell surface of astrocytes and interacts with target receptors in a juxtacrine manner. GMFB is involved in the differentiation of glial cells and neurons. It stimulates axon regeneration and proliferation of astroblasts, and inhibits proliferation of tumors. It also reversibly inhibits proliferation of neuronal and non-neuronal neoplastic cells by arresting the cell cycle in the G0/G1 phase. It is suggested that GMFB acts an intracellular regulator of signal pathways. Analysis of crystallography and NMR reveals structural differences between murine and human ADF-H domains.

Product Specifications

Catalog ID 1570-07
MW ~16.6 kDa
Storage/Handling Store desiccated at -20°C.
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1570-07-2 2 μg $ 76.00
1570-07-10 10 μg $ 112.00
1570-07-1000 1000 μg $ 1,795.00

MANF, Human

Catalog ID Size Pricing
1170-15-5 5 μg $ 76.00
1170-15-25 25 μg $ 112.00
1170-15-1000 1000 μg $ 1,437.00

Description

MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. MANF and its structural homolog CDNF each contain an N-terminal saposin-like lipid binding domain and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. MANF has been identified as a soluble ER stress protein induced by the unfolded protein response. MANF and CDNF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways, as shown in a rat experimental model of Parkinson disease.

Product Specifications

Catalog ID 1170-15
MW ~18.2 kDa
Storage/Handling Store desiccated at -20°C.
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1170-15-5 5 μg $ 76.00
1170-15-25 25 μg $ 112.00
1170-15-1000 1000 μg $ 1,437.00

MDK, Human

Catalog ID Size Pricing
1170-18-5 5 μg $ 76.00
1170-18-20 20 μg $ 112.00
1170-18-1000 1000 μg $ 1,437.00

Description

Midkine (MDK) is a heparin-binding growth factor that is expressed in various cell types during embryo development and in a variety of carcinomas. It is induced by retinoic acid, as well as during oncogenesis, inflammation, and tissue repair. MDK is pleiotropic and promotes angiogenesis, neurogenesis, chondrogenesis, cell growth, cell migration, and tumorigenesis. It also inhibits apoptosis in some cells. MDK acts through several different receptors including PTP, ALK, PTP-zeta, and LRP. The amino acid sequence of human MDK is about 50% homologous to human pleiotrophin (PTN).

Product Specifications

Catalog ID 1170-18
MW ~13.4 kDa
Storage/Handling Store desiccated at -20°C.
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1170-18-5 5 μg $ 76.00
1170-18-20 20 μg $ 112.00
1170-18-1000 1000 μg $ 1,437.00

MDK, Murine

Catalog ID Size Pricing
1370-18-5 5 μg $ 76.00
1370-18-20 20 μg $ 112.00
1370-18-1000 1000 μg $ 1,437.00

Description

Midkine (MDK) is a heparin-binding growth factor that is expressed in various cell types during embryo development and in a variety of carcinomas. It is induced by retinoic acid, as well as during oncogenesis, inflammation, and tissue repair. MDK is pleiotropic and promotes angiogenesis, neurogenesis, chondrogenesis, cell growth, cell migration, and tumorigenesis. It also inhibits apoptosis in some cells. MDK acts through several different receptors including PTP, ALK, PTP-zeta, and LRP. MDK shows significant homology to pleiotrophin (PTN).

Product Specifications

Catalog ID 1370-18
MW ~13.2 kDa
Storage/Handling Store desiccated at -20°C.
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1370-18-5 5 μg $ 76.00
1370-18-20 20 μg $ 112.00
1370-18-1000 1000 μg $ 1,437.00

MDK, Rat

Catalog ID Size Pricing
1570-18-5 5 μg $ 76.00
1570-18-20 20 μg $ 112.00
1570-18-1000 1000 μg $ 1,437.00

Description

Midkine (MDK) is a heparin-binding growth factor that is expressed in various cell types during embryo development and in a variety of carcinomas. It is induced by retinoic acid, as well as during oncogenesis, inflammation, and tissue repair. MDK is pleiotropic and promotes angiogenesis, neurogenesis, chondrogenesis, cell growth, cell migration, and tumorigenesis. It also inhibits apoptosis in some cells. MDK acts through several different receptors including PTP, ALK, PTP-zeta, and LRP. MDK shows significant homology to pleiotrophin (PTN). The amino acid sequence of Rat MDK is 99% homologous to human MDK.

Product Specifications

Catalog ID 1570-18
MW ~13.2 kDa
Storage/Handling Store desiccated at -20°C.
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1570-18-5 5 μg $ 76.00
1570-18-20 20 μg $ 112.00
1570-18-1000 1000 μg $ 1,437.00

NPPB, Human

Catalog ID Size Pricing
1170-09-20 20 μg $ 76.00
1170-09-100 100 μg $ 112.00
1170-09-1000 1000 μg $ 701.00

Description

Natriuretic Peptide B is synthesized as a 134 residue preprohormone before a signal peptide is cleaved, creating a storage protein which is further cleaved into the 32 residue, biologically active peptide that is secreted into the blood. NPPB was first discovered in porcine brain, but is produced mainly by cardiac ventricle cells in humans. It acts as a cardiac hormone with a variety of functions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Additionally, it plays a key role in cardiovascular homeostasis, helps restore the body's salt and water balance, and improves heart function. NPPB also has antimicrobial properties against Gram-positive and Gram-negative bacteria as well as yeast in a dose-dependent manner.

Product Specifications

Catalog ID 1170-09
MW ~3.5 kDa
Storage/Handling Store desiccated at -20°C.
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1170-09-20 20 μg $ 76.00
1170-09-100 100 μg $ 112.00
1170-09-1000 1000 μg $ 701.00

NRG1-alpha, Human

Catalog ID Size Pricing
1170-20-10 10 μg $ 76.00
1170-20-50 50 μg $ 112.00
1170-20-1000 1000 μg $ 1,173.00

Description

Neuregulin 1 belongs to a family of structurally related polypeptide growth factors and is produced in numerous isoforms by alternative splicing, which allows it to perform a wide variety of functions. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They all have the EGF-like domain, and can bind to ErbB3 and ErbB4 receptor tyrosine kinases. This binding induces ErbB3 and ErbB4 heterodimerization with ErbB2, stimulating intrinsic kinase activity. This product is the EGF-like domain of isoform 1. NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells. Isoform 1 induces differentiation of mammary tumor cells, including altered morphology and synthesis of milk components. NRG1 is necessary for cardiac development, structural maintenance, and functional integrity of the heart. It is also thought to play a role in synaptic plasticity. Dysregulation of NRG1 has been linked to various cancers and schizophrenia.

Product Specifications

Catalog ID 1170-20
MW ~7.4 kDa
Storage/Handling Store desiccated at -20°C.
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1170-20-10 10 μg $ 76.00
1170-20-50 50 μg $ 112.00
1170-20-1000 1000 μg $ 1,173.00

NRG1-beta1 (177-241 a.a.), Human

Catalog ID Size Pricing
1170-10B-10 10 μg $ 76.00
1170-10B-50 50 μg $ 112.00
1170-10B-1000 1000 μg $ 781.00

Description

Neuregulin 1 belongs to a family of structurally related polypeptide growth factors and is produced in numerous isoforms by alternative splicing, which allows it to perform a wide variety of functions. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They all have the EGF-like domain, and can bind to ErbB3 and ErbB4 receptor tyrosine kinases. This binding induces ErbB3 and ErbB4 heterodimerization with ErbB2, stimulating intrinsic kinase activity. This recombinant protein is the EGF-like domain (177-241 a.a.) of isoform 6, the major neuronal isoform. NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells. NRG1 is necessary for development, structural maintenance, and functional integrity of the heart. It is also thought to play a role in synaptic plasticity. Dysregulation of NRG1 has been linked to various cancers and schizophrenia.

Product Specifications

Catalog ID 1170-10B
MW ~7.5 kDa
Storage/Handling Store desiccated at -20°C.
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1170-10B-10 10 μg $ 76.00
1170-10B-50 50 μg $ 112.00
1170-10B-1000 1000 μg $ 781.00

NRG1-beta2, Human

Catalog ID Size Pricing
1170-10-10 10 μg $ 76.00
1170-10-50 50 μg $ 112.00
1170-10-100 100 μg $ 152.00
1170-10-250 250 μg $ 291.00
1170-10-500 500 μg $ 436.00
1170-10-1000 1000 μg $ 781.00

Description

Neuregulin 1 belongs to a family of structurally related polypeptide growth factors and is produced in numerous isoforms by alternative splicing, which allows it to perform a wide variety of functions. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They all have the EGF-like domain, and can bind to ErbB3 and ErbB4 receptor tyrosine kinases. This binding induces ErbB3 and ErbB4 heterodimerization with ErbB2, stimulating intrinsic kinase activity. This recombinant protein is the EGF-like domain of isoform 7. NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells. NRG1 is necessary for development, structural maintenance, and functional integrity of the heart. It is also thought to play a role in synaptic plasticity. Dysregulation of NRG1 has been linked to various cancers and schizophrenia.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Product Specifications

Catalog ID 1170-10
MW ~7.0 kDa
Storage/Handling Store desiccated at -20°C.
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1170-10-10 10 μg $ 76.00
1170-10-50 50 μg $ 112.00
1170-10-100 100 μg $ 152.00
1170-10-250 250 μg $ 291.00
1170-10-500 500 μg $ 436.00
1170-10-1000 1000 μg $ 781.00

NRN1, Human

There is no image for NRN1, Human NRN1, Human
Catalog ID Size Pricing
1170-22-5 5 μg $ 76.00
1170-22-20 20 μg $ 112.00
1170-22-1000 1000 μg $ 1,437.00

Description

Neuritin (NRN1) is a GPI-anchored neurotrophic factor, which is expressed in response to induction of neuronal activity by GDNF, BDNF, NT3 and other neural stimulators. It promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. NRN1 also promotes angiogenesis. During early brain development, NRN1 inhibits apoptosis of cortical progenitors by preventing activation of caspase 3. Recombinant human neuritin is a covalently disulfide-linked homodimer, consisting of two 9.7 kDa polypeptide monomers, each containing 88 amino acid residues.

Product Specifications

Catalog ID 1170-22
MW ~19.4 kDa
Storage/Handling Store desiccated at -20°C.
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1170-22-5 5 μg $ 76.00
1170-22-20 20 μg $ 112.00
1170-22-1000 1000 μg $ 1,437.00

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