PDGF & VEGF

The platelet derived growth factors (PDGF) family consists of five different PDGF isoforms, as well as placental growth factor (PGF) and members of the VEGF subfamily. These proteins all contain a conserved cystine-knot structure that is essential for receptor binding. Both PDGF and VEGF proteins play important roles in angiogenesis and vascularization, as well as in cell proliferation and migration. While members of both the PDGF and VEGF families act as ligands for tyrosine kinase receptors specific to their family, there is some evidence of cross-family receptor binding. GoldBio offers affordable, high quality recombinant proteins from the PDGF and VEGF families.
Showing 1-6 of 6 items.

PDGFAA (dimer), Rat

Catalog ID Size Pricing
1550-14-2 2 μg $ 76.00
1550-14-10 10 μg $ 112.00
1550-14-100 100 μg $ 394.00
1550-14-250 250 μg $ 723.00
1550-14-500 500 μg $ 1,080.00
1550-14-1000 1000 μg $ 1,795.00

Description

Platelet-derived growth factor (PDGF) is a glycoprotein present in serum but absent from plasma. PDGF has three subforms: PDGFAA, PDGFBB, and PDGF-AB. This form is a disulfide-linked homodimer consisting of two peptide chains A (PDGFAA). It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. The function of PDGF is mediated by two tyrosine kinase receptors, PDGFR-α and PDGFR-β. PDGFR-α is the receptor that binds PDGFAA.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Product Specifications

Catalog ID 1550-14
MW ~25.3 kDa
Storage/Handling Store desiccated at -20°C.
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1550-14-2 2 μg $ 76.00
1550-14-10 10 μg $ 112.00
1550-14-100 100 μg $ 394.00
1550-14-250 250 μg $ 723.00
1550-14-500 500 μg $ 1,080.00
1550-14-1000 1000 μg $ 1,795.00

PDGFBB (dimer), Human

Catalog ID Size Pricing
1150-10-2 2 μg $ 76.00
1150-10-10 10 μg $ 112.00
1150-10-100 100 μg $ 394.00
1150-10-250 250 μg $ 723.00
1150-10-500 500 μg $ 1,080.00
1150-10-1000 1000 μg $ 1,795.00

Description

Platelet-derived growth factor (PDGF) is a glycoprotein present in serum but absent from plasma. PDGF has three subforms: PDGFAA, PDGFBB, and PDGF-AB. This form is a disulfide-linked homodimer consisting of two peptide chains B (PDGFBB). It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. In contrast to PDGFAA, the beta chains in PDGFBB are sufficient for mitogenesis. The function of PDGF is mediated by two tyrosine kinase receptors, PDGFR-α and PDGFR-β, both of which bind PDGFBB.

Product Specifications

Catalog ID 1150-10
MW ~24.8 kDa
Storage/Handling Store desiccated at -20°C.
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1150-10-2 2 μg $ 76.00
1150-10-10 10 μg $ 112.00
1150-10-100 100 μg $ 394.00
1150-10-250 250 μg $ 723.00
1150-10-500 500 μg $ 1,080.00
1150-10-1000 1000 μg $ 1,795.00

VEGF120, Murine

Catalog ID Size Pricing
1350-06-2 2 μg $ 76.00
1350-06-10 10 μg $ 112.00
1350-06-100 100 μg $ 394.00
1350-06-250 250 μg $ 723.00
1350-06-500 500 μg $ 1,080.00
1350-06-1000 1000 μg $ 1,795.00

Description

Vascular Endothelial Growth Factor is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. VEGF is expressed in vascularized tissues and plays a prominent role in normal and pathological angiogenesis. VEGF has been implicated in the induction of tumor metastasis, intra-ocular neovascular syndromes and angiogenesis. Three mouse cDNA clones (monomeric VEGF having 120, 164 or 188 amino acids) have been identified through alternative splicing. Two receptor tyrosine kinases (RTKs), Flt-1 and Flk-1 (the mouse homologue of human KDR) have been shown to bind VEGF with high affinity.

Product Specifications

Catalog ID 1350-06
MW ~28.4 kDa
Storage/Handling Store desiccated at -20°C.
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1350-06-2 2 μg $ 76.00
1350-06-10 10 μg $ 112.00
1350-06-100 100 μg $ 394.00
1350-06-250 250 μg $ 723.00
1350-06-500 500 μg $ 1,080.00
1350-06-1000 1000 μg $ 1,795.00

VEGF164, Rat

Catalog ID Size Pricing
1550-07-2 2 μg $ 76.00
1550-07-10 10 μg $ 112.00
1550-07-100 100 μg $ 394.00
1550-07-250 250 μg $ 723.00
1550-07-500 500 μg $ 1,080.00
1550-07-1000 1000 μg $ 1,795.00

Description

Vascular endothelial growth factor is a potent growth factor and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells and promotes angiogenesis and vascular permeability. VEGF is expressed in vascularized tissues and plays a prominent role in normal and pathological angiogenesis. VEGF has been implicated in the induction of tumor metastasis, intra-ocular neovascular syndromes and angiogenesis. Two receptor tyrosine kinases (RTKs), Flt-1 and Flk-1 have been shown to bind VEGF with high affinity.

Product Specifications

Catalog ID 1550-07
MW ~38.2 kDa
Storage/Handling Store desiccated at -20°C.
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1550-07-2 2 μg $ 76.00
1550-07-10 10 μg $ 112.00
1550-07-100 100 μg $ 394.00
1550-07-250 250 μg $ 723.00
1550-07-500 500 μg $ 1,080.00
1550-07-1000 1000 μg $ 1,795.00

VEGF165, Human

Catalog ID Size Pricing
1150-05-2 2 μg $ 76.00
1150-05-10 10 μg $ 112.00
1150-05-100 100 μg $ 394.00
1150-05-250 250 μg $ 723.00
1150-05-500 500 μg $ 1,080.00
1150-05-1000 1000 μg $ 1,795.00

Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption! 

VEGF165 is an abundant glycosylated cytokine composed of two identical 165 amino acid chains in the Vascular Endothelial Growth Factor family. It plays a significant role in stimulating angiogenesis, not only during embryonic development, but also upon injury to vascular tissue or when blockage occurs. This growth factor is the most abundant and potent form in its family and uses a heparin-binding mechanism to induce angiogenesis. It has been shown to play a role in tumor metastasis by vascularizing metastatic tissues and to increase capillary permeability. In addition, VEGF165 tightly binds receptor tyrosine kinases Flk-1 and Flt-1. Recent studies implicate VEGF165 in production of osteoclasts in murine bone marrow.

Product Specifications

Catalog ID 1150-05
MW ~38.2 kDa
Storage/Handling Store desiccated at -20°C.
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Quick Add
1150-05-2 2 μg $ 76.00
1150-05-10 10 μg $ 112.00
1150-05-100 100 μg $ 394.00
1150-05-250 250 μg $ 723.00
1150-05-500 500 μg $ 1,080.00
1150-05-1000 1000 μg $ 1,795.00

VEGF165, Murine

Catalog ID Size Pricing
1350-07-2 2 μg $ 76.00
1350-07-10 10 μg $ 112.00
1350-07-100 100 μg $ 394.00
1350-07-250 250 μg $ 723.00
1350-07-500 500 μg $ 1,080.00
1350-07-1000 1000 μg $ 1,795.00

Description

Vascular Endothelial Growth Factor is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. VEGF is expressed in vascularized tissues and plays a prominent role in normal and pathological angiogenesis. VEGF has been implicated in the induction of tumor metastasis, intra-ocular neovascular syndromes and angiogenesis. Three mouse cDNA clones (monomeric VEGF having 120, 164 or 188 amino acids) have been identified through alternative splicing. Two receptor tyrosine kinases (RTKs), Flt-1 and Flk-1 (the mouse homologue of human KDR) have been shown to bind VEGF with high affinity.

Product Specifications

Catalog ID 1350-07
MW ~38.8 kDa
Storage/Handling Store desiccated at -20°C.
View
Quick Add
1350-07-2 2 μg $ 76.00
1350-07-10 10 μg $ 112.00
1350-07-100 100 μg $ 394.00
1350-07-250 250 μg $ 723.00
1350-07-500 500 μg $ 1,080.00
1350-07-1000 1000 μg $ 1,795.00

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