Pharmaceutical Intermediates

5-Aminoisophthalic acid is used in proteomics research.

5-Benzyloxyindole is a useful chemical reagent. It is used in preparation of indole and quinoline carbothioic acid amide derivatives. It is also used in various Friedel-Crafts alkylation reactions as well as specific C-3 alkenylation reactions and preparation of protein kinase (PKC) inhibitors.

5-Bromo-4-chloro-3-indoxyl-1-acetate is a histochemical substrate for esterase.

5-Bromo-4-chloro-3-indoxyl-3-acetate is a histochemical substrate for esterase.

5-Bromoindole is a heterocyclic building block and a potential GSK-3 inhibitor.

5-Bromoindole-2-carboxylic acid is a heterocyclic building block used to synthesize a variety of biochemical compounds. It was used in the discovery of indole inhibitors of MMP-13 and the synthesis of indolyl ethanones useful as indoleamine 2,3-dioxygenase inhibitors. Additionally, 5-Bromoindole-2-carboxylic acid is used to synthesize cis-diaminocyclohexane derivatives useful as Xa inhibitors as well as tubulin polymerization inhibitors and anticancer agents.

5-Chloroindole is researched for its use as an antidepressant, antiemetic, and anti-parkinson agent. It is useful in the synthesis of 5-chloro-tryptamine, which is an intermediate involved in the preparation of antihypertensive agents and tranquilizers.

5-Cyanoindole has a variety of applications. It is used to create electropolymer films and can function as an enzyme inhibitor. Additionally, 5-cyanoindole is involved in the preparation of dihydroisoquinolines, benzoylindoles, 4,5-dihydrocyclopenta[c]quinolones, and vinyl indoles.

5-Fluoro-DL-tryptophan is a fluorinated tryptophan analog that is capable of being incorporated into proteins. It may be incorporated into cyclic AMP receptor protein (CRP) to study ligand binding changes in E. coli. Additionally, it can serve as an internal standard in chromogenic analysis of tryptophan and other tryptophan derivatives. Metabolically, 5-fluoro-DL-tryptophan is a tryptophan antagonist.

5-Fluoro-L-tryptophan monohydrate is a tryptophan derivative incorporated into proteins during their synthesis. It is useful as a reporter group due 19F and provides a way to study enzyme mechanisms through NMR. 5-fluoro-L-tryptophan is nonspecifically cytotoxic due to malfunctioning enzymes containing 5-fluoro-Trp in place of Trp.

5-Fluoroindole is a reagent involved in a variety of biochemical preparation procedures including: preparation of 5-HT6 receptor ligands, immunosuppressive agents, tryptophan dioxygenase inhibitors, anticancer agents, antibacterial agents, sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors, selective serotonin reuptake inhibitors, and myeloperoxidase inhibitors.

5-Hydroxyindole is a reagent useful for a variety of preparation procedures, including: preparation of 5-vinyl-3-pyricindecarbonitrices as PKCϴ inhibitors, melanins, indole dopamine D2 receptor antagonists, anthranilic acids, anticancer agents, and tubulin inhibitors.

5-Hydroxyindole-2-carboxylic acid is used in a variety of preparation procedures, including: preparation of oxadiazole analogs as SH2 inhibitors of tyrosine kinase ZAP-70, peptidomimetic inhibitors of signal transducers and Stat3 activators, 5-hydroxyindole-2-carboxylic acid amides as histamine-3 receptor inverse agonists, melanins, and anticancer agents. Upon oxidation with KMnO₄, 5-hydroxyindole-2-carboxylic acid yields pyrrole-2,3,5-tricarboxylic acid.

5-Hydroxyindole-3-acetic acid is the primary serotonin metabolite and a biomarker researched for its implication in intestinal carcinoid syndrome. Additionally, 5-HIAA has been shown to be increased in diseases such as Celiac disease and Whipple disease.

5-Methoxy-2-methylindole is a reagent useful in a variety of procedures, including: palladium acetate catalyzed arylation reactions, enantioselective Friedel-Crafts alkylations, alkylindole synthesis, and cyclopentaindolone synthesis.

5-Methoxy-DL-tryptophan is an derivative of tryptophan.