Protease Inhibitors

Upon cell lysis, proteolytic enzymes are released, which reduces protein yield. Adding a protease inhibitor to your cell suspensions will prevent unwanted proteolysis during protein extraction. Gold Biotechnology provides a broad selection of protease inhibitors that are specific for your research needs. These reversible and irreversible inhibitors are active against a variety of cysteine and serine proteases, and are effective in protecting proteins during extractions.
Showing 1-13 of 13 items.

1,10-Phenanthroline monohydrate

Catalog ID Size Pricing
P-980-10 10 g $ 42.00
P-980-25 25 g $ 75.00
P-980-50 50 g $ 133.00
P-980-100 100 g $ 239.00
P-980-250 250 g $ 345.00

Description

No description available

Product Specifications

Catalog ID P-980
CAS # 5144-89-8
MW 198.22 g/mol
Storage/Handling Store desiccated under inert gas at room temperature.
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P-980-10 10 g $ 42.00
P-980-25 25 g $ 75.00
P-980-50 50 g $ 133.00
P-980-100 100 g $ 239.00
P-980-250 250 g $ 345.00

AEBSF

Catalog ID Size Pricing
A-540-500 500 mg $ 50.00
A-540-1 1 g $ 91.00
A-540-2.5 2.5 g $ 200.00
A-540-5 5 g $ 299.00
A-540-10 10 g $ 541.00
A-540-25 25 g $ 1,219.00

Description

AEBSF is an irreversible serine protease inhibitor. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin, kallikrein and thrombin. It inhibits by acylation of the active site of the enzyme. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25 mM. Aqueous solutions are stable between pH 5-6; limited stability above pH 7.5.

Product Specifications

Catalog ID A-540
CAS # 30827-99-7
MW 239.69 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at -20°C. Protect from light.
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A-540-500 500 mg $ 50.00
A-540-1 1 g $ 91.00
A-540-2.5 2.5 g $ 200.00
A-540-5 5 g $ 299.00
A-540-10 10 g $ 541.00
A-540-25 25 g $ 1,219.00

Aprotinin

Catalog ID Size Pricing
A-655-25 25 mg $ 46.00
A-655-100 100 mg $ 115.00

Description

Aprotinin is a monomeric globular polypeptide derived from bovine lung tissue. It consists of a chain of 58 amino acids that fold into a stable, compact tertiary structure of the 'small SS-rich" type, containing 3 disulfides, a twisted β-hairpin and a C-terminal α-helix.

Aprotinin inhibits several serine proteases, specifically trypsin, chymotrypsin, plasmin and kallikrein. Its action on kallikrein leads to the inhibition of the formation of factor XIIa. Binding is reversible with most aprotinin-protease complexes dissociating at pH >10 or < 3. Aprotinin is freely soluble in water (>10 mg/ml) as well as low ionic strength aqueous buffers.

Product Specifications

Catalog ID A-655
CAS # 9087-70-1
MW 6511.44 g/mol
Storage/Handling Store at 4°C.
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A-655-25 25 mg $ 46.00
A-655-100 100 mg $ 115.00

Asunaprevir

Catalog ID Size Pricing
A-820-10 10 mg $ 265.00
A-820-25 25 mg $ 530.00

Description

No description available

Product Specifications

Catalog ID A-820
CAS # 630420-16-5
MW 748.28 g/mol
Storage/Handling Store at -20°C.
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A-820-10 10 mg $ 265.00
A-820-25 25 mg $ 530.00

Benzamidine hydrochloride monohydrate

Catalog ID Size Pricing
B-050-100 100 g $ 63.00
B-050-500 500 g $ 225.00
B-050-1 1 kg $ 375.00
B-050-2.5 2.5 kg $ 773.00

Description

Benzamidine hydrochloride monohydrate is an aromatic amidine. It is used in protein extractions as a strong reversible inhibitor of serine proteases such as trypsin, thrombin, plasmin and other trypsin-like proteases. Compared to aprotinin, benzamidine is considered to be just as effective in preventing the degradation of glucogon.

Product Specifications

Catalog ID B-050
CAS # 1670-14-0
MW 174.63 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at -20°C. Protect from light.
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B-050-100 100 g $ 63.00
B-050-500 500 g $ 225.00
B-050-1 1 kg $ 375.00
B-050-2.5 2.5 kg $ 773.00

Bestatin

Catalog ID Size Pricing
B-915-100 100 mg $ 59.00
B-915-250 250 mg $ 133.00
B-915-500 500 mg $ 211.00
B-915-1 1 g $ 317.00

Description

No description available

Product Specifications

Catalog ID B-915
CAS # 58970-76-6
MW 308.37 g/mol
Storage/Handling Store at room temperature.
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B-915-100 100 mg $ 59.00
B-915-250 250 mg $ 133.00
B-915-500 500 mg $ 211.00
B-915-1 1 g $ 317.00

Carfilzomib

Catalog ID Size Pricing
C-915-5 5 mg $ 122.00
C-915-25 25 mg $ 477.00

Description

No description available

Product Specifications

Catalog ID C-915
CAS # 868540-17-4
MW 719.91 g/mol
Storage/Handling Store at 4°C.
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C-915-5 5 mg $ 122.00
C-915-25 25 mg $ 477.00

E-64

Catalog ID Size Pricing
E-064-25 25 mg $ 121.00
E-064-100 100 mg $ 286.00

Description

No description available

Product Specifications

Catalog ID E-064
CAS # 66701-25-5
MW 357.41 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at -20°C.
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E-064-25 25 mg $ 121.00
E-064-100 100 mg $ 286.00

Ixazomib Citrate

Catalog ID Size Pricing
I-350-10 10 mg $ 157.00

Description

No description available

Product Specifications

Catalog ID I-350
CAS # 1239908-20-3
MW 517.12 g/mol
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I-350-10 10 mg $ 157.00

Leupeptin Hemisulfate

Catalog ID Size Pricing
L-010-5 5 mg $ 42.00
L-010-25 25 mg $ 84.00
L-010-100 100 mg $ 275.00

Description

No description available

Product Specifications

Catalog ID L-010
CAS # 103476-89-7
MW 475.59 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at -20°C.
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L-010-5 5 mg $ 42.00
L-010-25 25 mg $ 84.00
L-010-100 100 mg $ 275.00

Pepstatin A

Catalog ID Size Pricing
P-020-5 5 mg $ 48.00
P-020-25 25 mg $ 108.00
P-020-100 100 mg $ 324.00

Description

Pepstatin A is a competitive, reversible aspartic protease inhibitor and inhibits proteases such as pepsin, chyomsin, renin, HIV proteases, and cathepsins D and E. Peptstatin A is highly selective and is often used in a mixture with other enzyme inhibitors. In vitro studies have shown pepstatin A is the only aspartic acid inhibitor that exhibits inhibitory effects on HIV proteases.

Pepstatin A is effective at inhibiting most affected proteases at a concentration of 1μM, but can inhibit pepsin at the picomolar range of concentrations. It is believed to function by way of a collected-substrate inhibition mechanism. Pepstatin A may also suppress differentiation of osteoclasts by inhibiting phosphorylation of MAP kinase and inhibiting NFATc1 expression.

Product Specifications

Catalog ID P-020
CAS # 26305-03-3
MW 685.89 g/mol
Grade MOLECULAR BIOLOGY GRADE
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P-020-5 5 mg $ 48.00
P-020-25 25 mg $ 108.00
P-020-100 100 mg $ 324.00

Phenylmethylsulfonyl fluoride (PMSF)

Catalog ID Size Pricing
P-470-10 10 g $ 53.00
P-470-25 25 g $ 98.00
P-470-50 50 g $ 187.00
P-470-100 100 g $ 282.00

Description

PMSF is a serine protease inhibitor that irreversibly inhibits serine proteases by sulfonylation of the serine residue in the active site of the protease. It is widely used in protocols for the isolation of proteins.

PMSF is inactivated in aqueous solutions. The rate of inactivation increases with increasing pH and is faster at 25°C than at 4°C. The half-life of a 20mM aqueous solution of PMSF is ~35 minutes at pH 8.0. This short half-life means that aqueous solutions of PMSF can be safely discarded after they have been rendered alkaline (pH >8.6) and stored for several hours at room temperature.

Product Specifications

Catalog ID P-470
CAS # 329-98-6
MW 174.19 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store desiccated at 4°C. Protect from light.
UN Number 2923
Item Class 8 (6.1)
Group Number II
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P-470-10 10 g $ 53.00
P-470-25 25 g $ 98.00
P-470-50 50 g $ 187.00
P-470-100 100 g $ 282.00

Trypsin Inhibitor, Soybean, Purified >10,000 U

There is no image for Trypsin Inhibitor, Soybean, Purified >10,000 U Trypsin Inhibitor, Soybean, Purified >10,000 U
Catalog ID Size Pricing
T-166-100 100 mg $ 75.00
T-166-500 500 mg $ 262.50
T-166-1 1 g $ 472.50

Description

No description available

Product Specifications

Catalog ID T-166
CAS # 9035-81-8
Grade HIGH PURITY GRADE
Storage/Handling Store desiccated at -20°C.
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T-166-100 100 mg $ 75.00
T-166-500 500 mg $ 262.50
T-166-1 1 g $ 472.50

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