NRG1-alpha, Human

Product Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Neuregulin 1 Alpha (NRG1-α)
Glial Growth Factor
Heregulin-Alpha (HRGA)
NEU Differentiation Factor (NDF)
Acetylcholine Receptor Inducing Activity
Breast Cancer Cell Differentiation Factor p45
Sensory and Motor Neuron-Derived Factor (SMDF)

Neuregulin 1 belongs to a family of structurally related polypeptide growth factors and is produced in numerous isoforms by alternative splicing, which allows it to perform a wide variety of functions. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They all have the EGF-like domain, and can bind to ErbB3 and ErbB4 receptor tyrosine kinases. This binding induces ErbB3 and ErbB4 heterodimerization with ErbB2, stimulating intrinsic kinase activity. This product is the EGF-like domain of isoform 1. NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells. Isoform 1 induces differentiation of mammary tumor cells, including altered morphology and synthesis of milk components. NRG1 is necessary for cardiac development, structural maintenance, and functional integrity of the heart. It is also thought to play a role in synaptic plasticity. Dysregulation of NRG1 has been linked to various cancers and schizophrenia.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~7.4 kDa (65 amino acids)

Purity: >97% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The ED 50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 40 ng/ml, corresponding to a specific activity of >2.5×104 IU/mg.

Storage/Handling: Store desiccated at -20°C.

HGNC: 7997

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM
UniProt

Product Specifications

Catalog ID 1170-20
MW ~7.4 kDa
Storage/Handling Store desiccated at -20°C.

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