Product Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human NOG
Noggin

Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β (Transforming Growth Factor) family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Noggin has been shown to modulate the activities of other BMPs including BMP2, 7, 13, and 14. Targeted deletion of noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Transgenic mice over-expressing noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation and severe osteoporosis.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~46.2 kDa (2x206 amino acid)
(A non-disulfide linked homodimer consisting of two 206 amino acid polypeptide chains)

Purity: >95% by SDS-PAGE and HPLC analyses

Storage/Handling: Store desiccated at -20°C.

HGNC ID: 7866

NOT FOR HUMAN USE!

Cross-species homology
Percent Similarity
HuNogginMuNoggin
HuNoggin*** 99.5
MuNoggin******

Additional resources for this protein may be found at:
OMIM

Product Specifications

Catalog ID 1180-09
MW ~46.2 kDa
Storage/Handling Store desiccated at -20°C.

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