CCL4, Rat

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Rat Chemokine (C-C motif) Ligand 4 (CCL4)
Macrophage Inflammatory Protein 1, Beta (MIP1B, MIP1B1)
Small Inducible Cytokine Subfamily A Member 4 (SCYA4)
Immune Activation 2 (ACT2, ACT-2)

Rat CCL4 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. It is expressed and secreted by T-cells, B-cells, monocytes, and various tumor cells lines. Expression of CCL4 is induced by IL2 and mitogens, such as phytohemmagglutinin, LPS, and the peptidoglycan wall of S. aureus and expression is inhibited by glucocorticoids, TGF-beta, and cyclosporin A. CCL4 is an HIV-suppressive factor and may contribute to amyloid deposition in Alzheimer disease. It also binds to HSV-1 virions and generates pores in the envelope of HSV-1. CCL4 is a ligand for CCR1, CCR3, CCR5, CCR8, and ACKR2 (D6).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~7.8 kDa (69 amino acids)

Purity: >95% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration of 10-1000 ng/ml.

Storage/Handling: Store desiccated at -20°C.

RGD: 620441

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM