Cefotaxime (Sodium) 100 mg/mL Solution
Cefotaxime is a third generation, broad-spectrum cephalosporin antibiotic effective against various gram-negative and gram-positive bacteria. However, unlike many other cephalosporins, cefotaxime is not effective against Pseudomonas aeruginosa bacteria. Cefotaxime is often used in Agrobacterium tumefaciens-mediated transformations to regulate bacterial growth. It has been shown to exhibit a synergistic effect with Vancomycin in certain conditions.
Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.
GoldBio’s antibiotic solutions are provided ready to use.
Cefotaxime Sodium in H2O
(100 mg/mL Premade Solution, 0.2 µm Sterile Filtered)
MOLECULAR BIOLOGY GRADE
MW: 477.45 g/mol
Storage/Handling: Store at -20°C.
PubChem Chemical ID: 10695961
|Grade||MOLECULAR BIOLOGY GRADE|
Agrobacterium tumefaciens-mediated transformation of Colletotrichum graminicola - method by Flowers and Vaillancourt (2005)
A brief explanation of the disk diffusion assay method used to test Gold Bio antibiotics
Examine the Effect of Carbenicilln, Cefotaxime and Vancomycin on Plant Morphogenesis by Teixeira da Silva, JA and S. Fukai (2001)