Product Description

E-64 (trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane) irreversibly inhibits cysteine proteases without affecting other enzymes that contain cysteine residues. E-64 is capable of inhibiting bromelain, trypsin, papain, staphopain, calpain, collagenase, ficain, cathepsin B, H and L. Inhibition of serine proteases is not seen with E-64, excepting trypsin.

E-64 is usually used in a concentration range of 1 to 10μM. It is widely used for in vivo studies due to its cell permeability, low toxicity, and potency. E-64 is being investigated for the treatment of diseases caused by cysteine protease activity. It has been observed to inhibit programmed cell death and restore antigen and mitogen activity related to normal proliferative responses in T cells obtained from HIV+ donors.

Product Specifications
E-64
trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane

MOLECULAR BIOLOGY GRADE

Formula: C15H27N5O5

MW: 357.41 g/mol

Storage/Handling: Store at -20°C.

PubChem Chemical ID: 123985

Product Specifications

Catalog ID E-064
CAS # 66701-25-5
MW 357.41 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at -20°C.

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