Nalidixic acid is a naphthyridone antibiotic that is similar in structure and mechanism to quinolones and is effective against both gram-positive and gram-negative bacteria. It acts as a bacteriostatic in lower concentrations but can be bacteriocidal at higher concentrations. Nalidixic acid indirectly inhibits proteins synthesis by binding DNA and interfering with enzymes involved in DNA replication and transcription and is commonly used in the treatment of urinary tract infections.
Nalidixic acid is freely soluble in methylene chloride, slightly soluble in water and is commonly used as a selective agent in many isolation medias; including Columbia Blood Agar and Fraser Broth.
MOLECULAR BIOLOGY GRADE
MW: 232.24 g/mol
Storage/Handling: Store at 4°C.
Soluble in methylene chloride and methanol. Slightly soluble in aqueous solutions (0.1 mg/ml).
|Grade||MOLECULAR BIOLOGY GRADE|
|Storage/Handling||Store at 4°C.|