Caspase 8 Polyclonal Antibody

Product Description

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]

Product Name
Caspase 8 Polyclonal Antibody
Caspase-8 Rabbit pAb
ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5; Caspase 8; CASP8; Caspase-8; caspase-8

Host Species
Rabbit

Purification Method
Affinity purification

Isotype
IgG

Storage/Handling
Store at -20℃. Avoid freeze / thaw cycles.

Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Immunogen Information

Immunogen
A synthesized peptide derived from human Caspase-8.

Gene ID: 841

Swiss Protein: Q14790

Calculated MW: 55 kDa

Observed MW: 55 kDa

Product Specifications

Catalog ID AB1232
Name Caspase 8 Polyclonal Antibody
Reactivity Human
Tested Applications WB
Recommended Dilution • WB 1:500 - 1:2000
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Positive Samples Jurkat, HepG2, HeLa

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