ABCA1 Polyclonal Antibody
Product Description
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
Product Name
ABCA1 Polyclonal Antibody
ABCA1 Rabbit pAb
ABCA1; ABC-1; ABC1; CERP; HDLDT1; TGD
Host Species
Rabbit
Purification Method
Affinity purification
Isotype
IgG
Storage/Handling
Store at -20℃. Avoid freeze / thaw cycles.
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Immunogen Information
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1870-2120 of human ABCA1 (NP_005493.2).
Sequence
IQYRFFIRPR PVNAKLSPLN DEDEDVRRER QRILDGGGQN DILEIKELTK IYRRKRKPAV DRICVGIPPG ECFGLLGVNG AGKSSTFKML TGDTTVTRGD AFLNKNSILS NIHEVHQNMG YCPQFDAITE LLTGREHVEF FALLRGVPEK EVGKVGEWAI RKLGLVKYGE KYAGNYSGGN KRKLSTAMAL IGGPPVVFLD EPTTGMDPKA RRFLWNCALS VVKEGRSVVL TSHSMEECEA LCTRMAIMVN G
Gene ID: 19
Swiss Protein: O95477
Calculated MW: 254 kDa
Observed MW: 254 kDa
Product Specifications
| Catalog ID | AB0020 |
|---|---|
| Name | ABCA1 Polyclonal Antibody |
| Reactivity | Human, Mouse |
| Tested Applications | WB |
| Recommended Dilution | • WB 1:500 - 1:2000 |
| Storage Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Positive Samples | A-431 |
| Cellular Location | Membrane, Multi-pass membrane protein |
