AKT1 Polyclonal Antibody

Product Description

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]

Product Name
AKT1 Polyclonal Antibody
AKT1 Rabbit mAb
AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA; AKT1

Host Species
Rabbit

Purification Method
Affinity purification

Isotype
IgG

Storage/Handling
Store at -20℃. Avoid freeze / thaw cycles.

Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Immunogen Information

Immunogen
A synthesized peptide derived from human AKT1

Gene ID: 207

Swiss Protein: P31749

Calculated MW: 56 kDa

Observed MW: 60 kDa

Product Specifications

Catalog ID AB0327
Name AKT1 Polyclonal Antibody
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF
Recommended Dilution • WB 1:500 - 1:2000
• IHC 1:50 - 1:200
• IF 1:50 - 1:200
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Positive Samples MCF7, DU145, NIH/3T3, Mouse thymus, Rat heart, Rat testis

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