BAX Polyclonal Antibody (KO Validated)

Product Description

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Product Name
BAX Polyclonal Antibody
Bax Rabbit mAb
BCL2L4; BAX

Host Species
Rabbit

Purification Method
Affinity purification

Isotype
IgG

Storage/Handling
Store at -20℃. Avoid freeze / thaw cycles.

Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Immunogen Information

Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human BAX (NP_620116.1).

Sequence
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF

Gene ID: 581

Swiss Protein: Q07812

Calculated MW: 4 kDa/12 kDa/15 kDa/18 kDa/19 kDa/21 kDa/24 kDa

Observed MW: 23 kDa

Product Specifications

Catalog ID AB0863
Name BAX Polyclonal Antibody
Reactivity Human, Mouse, Rat
Tested Applications WB, IF
Recommended Dilution • WB 1:500 - 1:1000
• IF 1:50 - 1:100
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Positive Samples MCF-7, HT-1080
Cellular Location Cytoplasm, Cytoplasm, Mitochondrion membrane, Single-pass membrane protein

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