Beclin 1 Polyclonal Antibody (KO Validated)
Product Description
This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants.
Product Name
Beclin 1 Polyclonal Antibody
Beclin 1 Rabbit pAb
ATG6; VPS30; beclin1; Beclin 1; BECN1; beclin-1
Host Species
Rabbit
Purification Method
Affinity purification
Isotype
IgG
Storage/Handling
Store at -20℃. Avoid freeze / thaw cycles.
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Immunogen Information
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human Beclin 1 (NP_003757.1).
Sequence
MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA QAKPGETQEE ETNSGEEPFI ETPRQDGVSR RFIPPARMMS TESANSFTLI GEASDGGTME NLSRRLKVTG DLFDIMSGQT DVDHPLCEEC TDTLLDQLDT QLNVTENECQ NYKRCLEILE QMNEDDSEQL QMELKELALE EERLIQELED VEKNRKIVAE NLEKVQAEAE RLDQEEAQYQ REYSEFKRQQ LELDDELKSV ENQMRYAQTQ LDKLKKTNVF NATFHIWHSG
Gene ID: 8678
Swiss Protein: Q14457
Calculated MW: 51 kDa
Observed MW: 60 kDaProduct Specifications
| Catalog ID | AB0918 |
|---|---|
| Name | Beclin 1 Polyclonal Antibody |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF, IP |
| Recommended Dilution |
• WB 1:500 - 1:2000 • IHC 1:50 - 1:200 • IF 1:50 - 1:200 • IP 1:50 - 1:100 |
| Storage Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Positive Samples | U-87MG, HeLa, MCF7, Mouse spleen, Rat ovary, Rat lung |
| Cellular Location | Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Endosome membrane, Golgi apparatus, Mitochondrion, Mitochondrion membrane, Nucleus, Peripheral membrane protein, autophagosome, trans-Golgi network membrane |
