CAT Polyclonal Antibody

Product Description

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene.

Product Name
CAT Polyclonal Antibody
CAT Rabbit pAb
CAT; catalase; MGC138422; MGC138424

Host Species
Rabbit

Purification Method
Affinity purification

Isotype
IgG

Storage/Handling
Store at -20℃. Avoid freeze / thaw cycles.

Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Immunogen Information

Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-225 of human CAT (NP_001743.1).

Sequence
MADSRDPASD QMQHWKEQRA AQKADVLTTG AGNPVGDKLN VITVGPRGPL LVQDVVFTDE MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITKYSKAKVF EHIGKKTPIA VRFSTVAGES GSADTVRDPR GFAVKFYTED GNWDLVGNNT PIFFIRDPIL FPSFIHSQKR NPQTHLKDPD MVWDFWSLRP ESLHQVSFLF SDRGIPDGHR HMNGYGSHTF KLVNA

Gene ID: 847

Swiss Protein: P04040

Calculated MW: 59 kDa

Observed MW: 59 kDa

Product Specifications

Catalog ID AB1247
Name CAT Polyclonal Antibody
Reactivity Human, Mouse, Rat
Tested Applications WB, IP
Recommended Dilution • WB 1:1000 - 1:3000
• IP 1:20 - 1:50
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Positive Samples HeLa, 293T, HepG2, Mouse kidney, Mouse liver, Rat kidney, Rat liver
Cellular Location Peroxisome

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