c-Myc Polyclonal Antibody

Product Description

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

Product Name
c-Myc Polyclonal Antibody
c-Myc Rabbit pAb
MRTL; MYCC; bHLHe39; c-Myc; MYC

Host Species
Rabbit

Purification Method
Affinity purification

Isotype
IgG

Storage/Handling
Store at -20℃. Avoid freeze / thaw cycles.

Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Immunogen Information

Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human c-Myc (NP_002458.2).

Sequence
MDFFRVVENQ QPPATMPLNV SFTNRNYDLD YDSVQPYFYC DEEENFYQQQ QQSELQPPAP SEDIWKKFEL LPTPPLSPSR RSGLCSPSYV AVTPFSLRGD

Gene ID: 4609

Swiss Protein: P01106

Calculated MW: 48 kDa/50 kDa

Observed MW: 49 kDa

Product Specifications

Catalog ID AB1874
Name c-Myc Polyclonal Antibody
Reactivity Human, Mouse, Rat
Tested Applications WB
Recommended Dilution • WB 1:500 - 1:2000
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Positive Samples HeLa, HL-60, MCF7, Mouse liver
Cellular Location Nucleus, nucleolus, nucleoplasm

Add To Cart

Catalog Number:
{{ currentSelection && currentSelection.sku ? currentSelection.sku : '...' }}
CAS Number:
{{ casNumber && casNumber.value ? casNumber.value : '...' }}
Size:
Quantity:
On Sale:
${{ currentSelection.price }} ${{ currentSelection.sale_price }}
Shipping:
Next day shipping required.

Join our list to receive promos and articles.

Join Now