Product Description

Ascomycin, also known as FK520, is a macrolide immunosuppressant produced by the bacterium Streptomyces hygroscopicus var. ascomyceticus. It is an ethyl analogue of FK506 and is used for post-transplant organ rejection, autoimmune disorders and neurodegeneration.

Ascomycin inhibits T-cell activation and development by binding to calcineurin. Calcineurin is a phosphatase that dephosphorylates nuclear factors of activated T-cells. Calcineurin inhibition prevents production of interleukin 2 (IL2), interleukin 4 (IL4), and the release of cytokines.

Product Specifications

Formula: C43H69NO12

MW: 792.00 g/mol

Storage/Handling: Store desiccated at -20°C.
Soluble in methanol.

PubChem Chemical ID: 5282071

Product Specifications

Catalog ID A-555
CAS # 11011-38-4
MW 792.00 g/mol

Add To Cart

Catalog Number:
{{ currentSelection && currentSelection.sku ? currentSelection.sku : '...' }}
CAS Number:
{{ casNumber && casNumber.value ? casNumber.value : '...' }}
On Sale:
${{ currentSelection.price }} ${{ currentSelection.sale_price }}
$9.99 Ground shipping (In continental US only.)

Join our list to receive promos and articles.

Join Now