Product Description

Ascomycin, also known as FK520, is a macrolide immunosuppressant produced by the bacterium Streptomyces hygroscopicus var. ascomyceticus. It is an ethyl analogue of FK506 and is used for post-transplant organ rejection, autoimmune disorders and neurodegeneration.

Ascomycin inhibits T-cell activation and development by binding to calcineurin. Calcineurin is a phosphatase that dephosphorylates nuclear factors of activated T-cells. Calcineurin inhibition prevents production of interleukin 2 (IL2), interleukin 4 (IL4), and the release of cytokines.

Product Specifications
Ascomycin
Immunomycin
FK520

Formula: C43H69NO12

MW: 792.00 g/mol

Storage/Handling: Store desiccated at -20°C.
Soluble in methanol.

PubChem Chemical ID: 5282071

Product Specifications

Catalog ID A-555
CAS # 11011-38-4
MW 792.00 g/mol

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