Cidofovir dihydrate is an acyclic analog of deoxycytidine monophosphate that is used as an antiviral. It targets a wide range of DNA viruses including, Poxviridae, Papillomaviridae and a high degree of activity against cytomegaloviruses.
Cidofovir dihydrate interrupts viral proliferation by inhibiting viral DNA synthesis. Host cell protein kinases phosphorylate cidofovir dihydrate to its active form cidofovir diphosphate. The active metabolite competes with deoxycytidine triphosphate for the viral DNA polymerase. Incorporation of Cidofovir diphosphate into the DNA strand halts synthesis and viral replication.
Formula: C8H14N3O6P • 2 H2O
MW: 315.22 g/mol
Storage/Handling: Store at room temperature.
PubChem Chemical ID: 60933