Caspase 1 Polyclonal Antibody

Product Description

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Product Name
Caspase 1 Polyclonal Antibody
Caspase-1 Rabbit pAb
CASP1; ICE; IL1BC; P45; caspase-1; Caspase 1

Host Species
Rabbit

Purification Method
Affinity purification

Isotype
IgG

Storage/Handling
Store at -20℃. Avoid freeze / thaw cycles.

Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Immunogen Information

Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-311 of human Caspase-1 (NP_150635.1).

Sequence
MADKVLKEKR KLFIRSMGEA PQAVQDNPAM PTSSGSEGNV KLCSLEEAQR IWKQKSAEIY PIMDKSSRTR LALIICNEEF DSIPRRTGAE VDITGMTMLL QNLGYSVDVK KNLTASDMTT ELEAFAHRPE HKTSDSTFLV FMSHGIREGI CGKKHSEQVP DILQLNAIFN MLNTKNCPSL KDKPKVIIIQ ACRGDSPGVV WFKDSVGVSG NLSLPTTEEF EDDAIKKAHI EKDFIAFCSS TPDNVSWRHP TMGSVFIGRL IEHMQEYACS CDVEEIFRKV RFSFEQPDGR AQMPTTERVT LTRCFYLFPG H

Gene ID: 834

Swiss Protein: P29466

Calculated MW: 10 kDa/29 kDa/35 kDa/42 kDa/45 kDa

Observed MW: 20 kDa/45 kDa

Product Specifications

Catalog ID AB1228
Name Caspase 1 Polyclonal Antibody
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF, IP
Recommended Dilution • WB 1:500 - 1:2000
• IHC 1:50 - 1:200
• IF 1:50 - 1:200
• IP 1:50 - 1:100
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Positive Samples THP-1, HeLa, mouse lung
Cellular Location Cytoplasm

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