CAV1 Polyclonal Antibody

Product Description

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

Product Name
CAV1 Polyclonal Antibody
CAV1 Rabbit pAb
BSCL3; CGL3; LCCNS; MSTP085; PPH3; VIP21; CAV1

Host Species
Rabbit

Purification Method
Affinity purification

Isotype
IgG

Storage/Handling
Store at -20℃. Avoid freeze / thaw cycles.

Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Immunogen Information

Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human CAV1 (NP_001744.2).

Sequence
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADELSEKQ VYDAHTKEID LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY

Gene ID: 857

Swiss Protein: Q03135

Calculated MW: 17 kDa/20 kDa

Observed MW: 20 kDa

Product Specifications

Catalog ID AB1248
Name CAV1 Polyclonal Antibody
Reactivity Human, Mouse
Tested Applications WB
Recommended Dilution • WB 1:500 - 1:2000
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Positive Samples A-549, HeLa, U-87MG, Mouse lung
Cellular Location Cell membrane, Golgi apparatus membrane, Membrane, Membrane raft, Peripheral membrane protein, caveola

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