Tobramycin is an aminoglycoside antibiotic isolated from Streptomyces tenebrarius targeting gram-negative bacteria. It is often used to combat Pseudomonas species. It has been used to study cystic fibrosis and a variety of respiratory infections. Tobramycin is freely soluble in aqueous solution.
Aminoglycoside antibiotics are composed of amino groups attached to glycosides. They bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation. Consequently, protein synthesis is inhibited.
Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
MOLECULAR BIOLOGY GRADE
MW: 467.51 g/mol
Storage/Handling: Store at 2-8°C.
PubChem Chemical ID: 36294
|Grade||MOLECULAR BIOLOGY GRADE|
|Storage/Handling||Store at 4°C.|