Vascular Endothelial Growth Factor is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. VEGF is expressed in vascularized tissues and plays a prominent role in normal and pathological angiogenesis. VEGF has been implicated in the induction of tumor metastasis, intra-ocular neovascular syndromes and angiogenesis. Three mouse cDNA clones (monomeric VEGF having 120, 164 or 188 amino acids) have been identified through alternative splicing. Two receptor tyrosine kinases (RTKs), Flt-1 and Flk-1 (the mouse homologue of human KDR) have been shown to bind VEGF with high affinity.

Vascular Endothelial Growth Factor is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. VEGF is expressed in vascularized tissues and plays a prominent role in normal and pathological angiogenesis. VEGF has been implicated in the induction of tumor metastasis, intra-ocular neovascular syndromes and angiogenesis. Three mouse cDNA clones (monomeric VEGF having 120, 164 or 188 amino acids) have been identified through alternative splicing. Two receptor tyrosine kinases (RTKs), Flt-1 and Flk-1 (the mouse homologue of human KDR) have been shown to bind VEGF with high affinity.

Vascular endothelial growth factor is a potent growth factor and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells and promotes angiogenesis and vascular permeability. VEGF is expressed in vascularized tissues and plays a prominent role in normal and pathological angiogenesis. VEGF has been implicated in the induction of tumor metastasis, intra-ocular neovascular syndromes and angiogenesis. Two receptor tyrosine kinases (RTKs), Flt-1 and Flk-1 have been shown to bind VEGF with high affinity.