DMNPE-caged Luciferin

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Description

Tested and Certified for in vivo imaging (See "Luciferin FAQ" in additional information)

Luciferin is a common bioluminescent reporter used for in vivo imaging of the expression of the luciferase . This substrate for the firefly luciferase enzyme utilizes ATP and Mg2+ as cofactors and emits a characteristic yellow-green emission in the presence of oxygen, which shifts to red light in vivo at 37°C.

Luciferin is a common reagent used throughout the biotechnology field and specifically for in vivo imaging. Luciferase labeled tumor cells, stem cells or infectious diseases are often inoculated into research animals such as rats or mice for investigation. The injection of luciferin allows for the real-time, noninvasive monitoring of disease progression and/or drug efficacy in these model systems through Bioluminescence Imaging (BLI).

DMNPE-caged luciferin can be used to measure intracellular functions since it readily crosses cell membranes. Once it is inside the cell, active luciferin can be released by UV light or by the action of endogenous intracellular esterases. DMNPE-caged luciferin makes it easier to follow the changes in gene expression in live cells. It can also be used in combination with DMNPE-caged ATP.

Product Specifications:

DMNPE-caged Luciferin

D-Luciferin 1- (4,5-dimethoxy-2- nitrophenyl) ethyl ester

MOLECULAR BIOLOGY GRADE

Color: Light yellow powder

Formula: C21H19N3O7S2

MW: 489.53 g/mol

Soluble in DMSO or DMF.

Storage: Store desiccated at -20°C, protect from light.

PubChem CID: 2762658

DMNPE-caged Luciferin

View Sizes & Pricing

Catalog Number:
L-130-50
CAS Number:
223920-67-0
$585.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
In stock
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Tested and Certified for in vivo imaging (See "Luciferin FAQ" in additional information)

    Luciferin is a common bioluminescent reporter used for in vivo imaging of the expression of the luciferase . This substrate for the firefly luciferase enzyme utilizes ATP and Mg2+ as cofactors and emits a characteristic yellow-green emission in the presence of oxygen, which shifts to red light in vivo at 37°C.

    Luciferin is a common reagent used throughout the biotechnology field and specifically for in vivo imaging. Luciferase labeled tumor cells, stem cells or infectious diseases are often inoculated into research animals such as rats or mice for investigation. The injection of luciferin allows for the real-time, noninvasive monitoring of disease progression and/or drug efficacy in these model systems through Bioluminescence Imaging (BLI).

    DMNPE-caged luciferin can be used to measure intracellular functions since it readily crosses cell membranes. Once it is inside the cell, active luciferin can be released by UV light or by the action of endogenous intracellular esterases. DMNPE-caged luciferin makes it easier to follow the changes in gene expression in live cells. It can also be used in combination with DMNPE-caged ATP.

    Product Specifications:

    DMNPE-caged Luciferin

    D-Luciferin 1- (4,5-dimethoxy-2- nitrophenyl) ethyl ester

    MOLECULAR BIOLOGY GRADE

    Color: Light yellow powder

    Formula: C21H19N3O7S2

    MW: 489.53 g/mol

    Soluble in DMSO or DMF.

    Storage: Store desiccated at -20°C, protect from light.

    PubChem CID: 2762658

    Product Specifications

    Catalog ID: L-130
    CAS #: 223920-67-0
    Formula: C21H19N3O7S2
    MW: 489.53 g/mol
    Grade: MOLECULAR BIOLOGY GRADE
    Storage/handling: Store desiccated at -20°C. Protect from light.
    PubChem Chemical ID: 2762658
    IUPAC Name: 1-(4,5-dimethoxy-2-nitrophenyl)ethyl (4S)-2-(6-hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylate
    InChI: InChI=1S/C21H19N3O7S2/c1-10(12-7-16(29-2)17(30-3)8-15(12)24(27)28)31-21(26)14-9-32-19(23-14)20-22-13-5-4-11(25)6-18(13)33-20/h4-8,10,14,25H,9H2,1-3H3/t10?,14-/m1/s1
    InChIKey: VGEMOUFKGRGCNZ-LNUXAPHWSA-N
    SMILES: CC(C1=CC(=C(C=C1[N+](=O)[O-])OC)OC)OC(=O)C2CSC(=N2)C3=NC4=C(S3)C=C(C=C4)O

    CITATIONS

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