" ["hide"]=> int(0) ["third_party_id"]=> int(249) ["featured_image_id"]=> int(0) ["banner_image_id"]=> int(0) ["meta_description"]=> string(155) "GoldBio carries a variety of top-quality anti-cancer and chemotherapeutic products for research, including apoptosis inducers and growth factor inhibitors." ["meta_keywords"]=> string(0) "" ["root_sort"]=> int(0) ["type"]=> string(7) "product" ["condition_type"]=> int(1) ["condition_match_type"]=> int(1) ["sort_type"]=> int(1) ["items_per_page"]=> int(25) ["color"]=> NULL } ["_oldAttributes":"yii\db\BaseActiveRecord":private]=> array(23) { ["id"]=> int(83) ["root"]=> int(1) ["lft"]=> int(136) ["rgt"]=> int(137) ["level"]=> int(3) ["name"]=> string(11) "Anti-Cancer" ["url_name"]=> string(11) "anti-cancer" ["title"]=> NULL ["short_description"]=> string(0) "" ["long_description"]=> string(415) "Gold Biotechnology is committed to carrying only the highest grade anti-cancer or chemotherapeutic products for the cancer research field. Our cancer research reagents include apoptosis inducers, antitumor antimicrobials, growth factor inhibitors, drug precursors, dyes and stains. GoldBio provides the best quality cancer research reagents so that you can develop the best chemotherapeutic research strategies.
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Antibiotics and Selection tools allow you to selectively control which cells can be found in your cultures.
GoldBio’s broad range of cell selection tools, including hundreds of antibiotics, antifungals and anticancers, plant selection and screening agents allow you to select, control and maintain your cell cultures with confidence and ease, no matter what cells you may be studying.
Antibiotics and Selection tools allow you to selectively control which cells can be found in your cultures.
GoldBio’s broad range of cell selection tools, including hundreds of antibiotics, antifungals and anticancers, plant selection and screening agents allow you to select, control and maintain your cell cultures with confidence and ease, no matter what cells you may be studying.
Shop a variety of antibiotics with broad or narrow spectrums of activity for your research. Gold Biotechnology offers high-quality antibiotics for wide range of target microorganisms, such as bacteria, fungi, viruses, or parasites.
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Product Description
Artesunate is a synthetic compound that is highly employed for its anti-malarial capabilities and is currently studied for its applications in oncology research and surgical procedures. In anti-malarial studies, it has been shown to disrupt EXP1 activity, which is a glutathione transferase responsible for cell detoxification in Plasmodium falciparum. Artesunate activity has been shown to be enhanced when co-administered with amodiaquine HCl.
In oncology research, Artesunate is used to arrest cancer growth in the G2/M phase and upregulate proteins p21 and Beclin1. These proteins are mainly related to apoptosis with p21 being a regulator of the process and Beclin1 playing a role in cell death by autophagy. Artesunate has also been shown to form an endoperoxide bridge which generates carbon radicals that dismantle the cell. However, the observed radical formation is dose and time dependent.
Artesunate has been shown to provide organ damage reduction in rats exposed to hemorrhagic shock. Administration of ART occurred after resuscitation and did not function as a preventative. Artesunate operates by decreasing cell apoptosis through protein kinase B (PKB) stimulation and glycogen synthase kinase inhibition. Cell survival is also enhanced by nuclear factor kappa B (NfkB) suppression, diminishing proinflammatory cytokine synthesis.
Product Specifications
Artesunate
Beta-artesunate
Formula: C19H28O8
MW: 384.42 g/mol
Storage/Handling: Store desiccated at room temperature.
Soluble in ethanol, acetone, chloroform.
PubChem Chemical ID: 65664
NOT FOR HUMAN USE!
Product Specifications
Catalog ID | A-670 |
---|---|
CAS # | 88495-63-0 |
MW | 384.42 g/mol |