Ceftriaxone free acid

Product Description

Ceftriaxone free acid is a β-lactam cephalosporin compound known for its potent antibiotic activity against gram negative and gram positive bacteria. It also has been observed to cross the blood brain barrier and has been used for both antibiotic and investigative purposes for the central nervous system (CNS).

Ceftriaxone has also been used in vivo for suppressing addictive behavior in rats. Researchers had shown ceftriaxone to upregulate glutamate transporter 1 (GLT1) expression, which diminishes glutamate concentration in synaptic clefts of the CNS. Ceftriaxone has been shown to effectively decrease glutamate levels which prevents hyper-stimulation of glutamic receptors and concurrently withdrawal symptoms.

Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Ceftriaxone free acid
Ceftriaxone

Formula: C18H18N8O7S3

MW: 554.58 g/mol

Storage/Handling: Store at -20°C.

PubChem Chemical ID: 5479530

Product Specifications

Catalog ID C-435
CAS # 73384-59-5
MW 554.58 g/mol

View Sizes & Pricing

Catalog Number:
{{ currentSelection && currentSelection.sku ? currentSelection.sku : '...' }}
CAS Number:
{{ casNumber && casNumber.value ? casNumber.value : '...' }}
Size:
Quantity:
On Sale:
${{ currentSelection.price }} ${{ currentSelection.sale_price }}
Shipping:
$9.99 Ground shipping (In continental US only.)

Join our list to receive promos and articles.

Join Now