Emodin is a compound used as an anti-inflammatory and anti-cancer agent. It has been shown that emodin suppresses inflammatory responses in vitro by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) protein complexes. This effect occurs from emodin binding and preserving an inhibitory subunit on NF-κB.
Emodin has also been shown to induce apoptosis in mouse neuroectodermal tumors both in vivo and in vitro. Cell death is induced by inhibiting protein tyrosine kinase (PTK), a regulator of cell growth. Constraining PTK activity prevents further cell development which signals an apoptotic cascade.
MW: 270.24 g/mol
Storage/Handling: Store desiccated at 4°C.
PubChem Chemical ID: 3220