8-Hydroxyquinoline

Product Description

8-Hydroxyquinoline is an organic compound that is used as a RNA inhibitor, anti-cancer agent and bidentate chelating agent. In vitro studies against Escherichia coli had shown 8-hydroxyquinoline inhibiting RNA polymerase activity. The enzyme’s activity was inhibited by chelating manganese, magnesium or zinc cofactors. Activity of 8-hydroxyquinoline toward RNA polymerase is broad and inhibits the synthesis of vertebrate RNA as well as proteins.

8-Hydroxyquinoline has also been used as an immobile chelating agent to remove transition metals, alkali and alkaline cations from solutions or within organisms. Its capability to bind the positively charged metals has been shown in vivo to inhibit proteasome activity in tumor cells by transporting copper ions into malignant cells. Halting proteasome activity was observed in vitro and in vivo with decreased cancer growth due to apoptosis.

Product Specifications
8-Hydroxyquinoline

Formula: C9H7NO

MW: 145.16 g/mol

Storage/Handling: Store desiccated at 4°C.

PubChem Chemical ID: 1923

NOT FOR HUMAN USE!!

Product Specifications

Catalog ID H-605
CAS # 148-24-3
MW 145.16 g/mol

View Sizes & Pricing

Catalog Number:
{{ currentSelection && currentSelection.sku ? currentSelection.sku : '...' }}
CAS Number:
{{ casNumber && casNumber.value ? casNumber.value : '...' }}
Size:
Quantity:
On Sale:
${{ currentSelection.price }} ${{ currentSelection.sale_price }}
Shipping:
$9.99 Ground shipping (In continental US only.)

Join our list to receive promos and articles.

Join Now