Isoxanthohumol

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Description

Isoxanthohumol is a prenylflavonoid compound extracted from Humulus lupulus L., the common hop plant. It has displayed strong estrogenic effects and has been used for anti-cancer research. Isoxanthohumol has also been shown to form the potent phytoestrogen 8-prenylnaringenin (8PN), which forms by cleaving off an ether group.

Oncology research on Isoxanthohumol activity has shown a significant degree of efficacy against breast, prostate and colon cancer cell lines. It has also been to shown to attenuate transforming growth factor-β (TGF-1 β) expression and disrupt Janus kinase/ signal transducer and activator of transcription (JAK/STAT) pathways which activate oncogenic genes.

Product Specifications
Isoxanthohumol

Formula: C21H22O5

MW: 354.40 g/mol

Storage/Handling: Store desiccated at 4°C.

PubChem Chemical ID: 513197

Isoxanthohumol

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Catalog Number:
I-820-1
CAS Number:
521-48-2
$90.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Isoxanthohumol is a prenylflavonoid compound extracted from Humulus lupulus L., the common hop plant. It has displayed strong estrogenic effects and has been used for anti-cancer research. Isoxanthohumol has also been shown to form the potent phytoestrogen 8-prenylnaringenin (8PN), which forms by cleaving off an ether group.

    Oncology research on Isoxanthohumol activity has shown a significant degree of efficacy against breast, prostate and colon cancer cell lines. It has also been to shown to attenuate transforming growth factor-β (TGF-1 β) expression and disrupt Janus kinase/ signal transducer and activator of transcription (JAK/STAT) pathways which activate oncogenic genes.

    Product Specifications
    Isoxanthohumol

    Formula: C21H22O5

    MW: 354.40 g/mol

    Storage/Handling: Store desiccated at 4°C.

    PubChem Chemical ID: 513197

    Product Specifications

    Catalog ID: I-820
    CAS #: 521-48-2
    Formula: C21H22O5
    MW: 354.40 g/mol
    Storage/handling: Store desiccated at 4°C.
    PubChem Chemical ID: 513197
    IUPAC Name: 7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
    InChI: InChI=1S/C21H22O5/c1-12(2)4-9-15-16(23)10-19(25-3)20-17(24)11-18(26-21(15)20)13-5-7-14(22)8-6-13/h4-8,10,18,22-23H,9,11H2,1-3H3
    InChIKey: YKGCBLWILMDSAV-UHFFFAOYSA-N
    SMILES: CC(=CCC1=C2C(=C(C=C1O)OC)C(=O)CC(O2)C3=CC=C(C=C3)O)C

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