Geniposide

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Description

Geniposide is a bioactive monosaccharide-derived molecule with a multitude of chemical identities including indoid glycoside, terpene glycoside and β-D-glucoside. It is also considered an enoate ester and cyclopentapyran. As a plant derivative glycoside, it has displayed medicinal properties in neuroprotective, antioxidant, anti-diabetic and anti-proliferative functions.

Geniposide’s neuroprotective and antioxidant qualities have been attributed to its ability to regulate Nrf2 translocation, affecting PI3K/Akt signaling pathway expression of antioxidant protein HO-1. As an agonist to the GLP-1 receptor, it’s demonstrated inhibition of oxidative damage from PC12 cells.

It’s regulation of glucose-stimulated insulin signaling also links it to diabetes and Alzheimer’s disease studies. Geniposide has been observed to up-regulate β-site APP cleaving enzyme (BACE1) and insulin-degrading enzyme (IDE), adversely reducing Aβ1-42 and ADAM10 levels. Geniposide research in correlation with formaldehyde has proved it to be an inhibitor of misfolding and aggregation of Tau protein and β amyloid protein, both characteristics of Alzheimer’s disease.

Product Specifications
Geniposide
(+)-geniposide

Formula: C17H24O10

MW: 388.37 g/mol

Storage/Handling: Store at room temperature.

PubChem Chemical ID: 107848

Geniposide

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Catalog Number:
G-750-25
CAS Number:
24512-63-8
$388.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Geniposide is a bioactive monosaccharide-derived molecule with a multitude of chemical identities including indoid glycoside, terpene glycoside and β-D-glucoside. It is also considered an enoate ester and cyclopentapyran. As a plant derivative glycoside, it has displayed medicinal properties in neuroprotective, antioxidant, anti-diabetic and anti-proliferative functions.

    Geniposide’s neuroprotective and antioxidant qualities have been attributed to its ability to regulate Nrf2 translocation, affecting PI3K/Akt signaling pathway expression of antioxidant protein HO-1. As an agonist to the GLP-1 receptor, it’s demonstrated inhibition of oxidative damage from PC12 cells.

    It’s regulation of glucose-stimulated insulin signaling also links it to diabetes and Alzheimer’s disease studies. Geniposide has been observed to up-regulate β-site APP cleaving enzyme (BACE1) and insulin-degrading enzyme (IDE), adversely reducing Aβ1-42 and ADAM10 levels. Geniposide research in correlation with formaldehyde has proved it to be an inhibitor of misfolding and aggregation of Tau protein and β amyloid protein, both characteristics of Alzheimer’s disease.

    Product Specifications
    Geniposide
    (+)-geniposide

    Formula: C17H24O10

    MW: 388.37 g/mol

    Storage/Handling: Store at room temperature.

    PubChem Chemical ID: 107848

    Product Specifications

    Catalog ID: G-750
    CAS #: 24512-63-8
    Formula: C17H24O10
    MW: 388.37 g/mol
    Storage/handling: Store at room temperature.
    UN number: 2811
    group number: III
    item class: 6.1
    PubChem Chemical ID: 107848
    IUPAC Name: methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate
    InChI: InChI=1S/C17H24O10/c1-24-15(23)9-6-25-16(11-7(4-18)2-3-8(9)11)27-17-14(22)13(21)12(20)10(5-19)26-17/h2,6,8,10-14,16-22H,3-5H2,1H3/t8-,10-,11-,12-,13+,14-,16+,17+/m1/s1
    InChIKey: IBFYXTRXDNAPMM-BVTMAQQCSA-N
    SMILES: COC(=O)C1=COC(C2C1CC=C2CO)OC3C(C(C(C(O3)CO)O)O)O

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