Mildronate is a pharmaceutical amino acid amide believed to stimulate vasodilation, thus used to treat angina and myocardial infraction. Chemically, it identifies with aromatic ethers and secondary alcohols. It is a substrate for γ-butyrobetaine dioxygenase and structural analogue of γ-butyrobetaine, competitively inhibiting by binding to the γ-butyrobetaine hydroxylase substrate.
It is a biological regulator to alpha 2-adrenergic receptors as well as nitric oxide-dependent mechanisms, functions which reduce blood glucose concentrations through oxidation. In ocular and cerebral ischemia, Mildronate decreases symptoms of circulatory disturbance through inhibition of carnitine synthesis.
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