Description
Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It is commonly used to study protein synthesis. Aside from its efficacy against bacteria, fungi, and higher eukaryotic cells, hygromycin B is also an antiviral agent inhibiting translation upon selectively entering cells made permeable due to viral infection. It works as a standard selection antibiotic in gene experiments, especially for selection of hygromycin resistance gene transformed cells.
Aminoglycoside antibiotics are composed of amino groups attached to glycosides. They bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translation. Consequently, protein synthesis is inhibited.
TESTED AGAINST BOTH SENSITIVE AND RESISTANT CELLS AT GOLD BIOTECHNOLOGY LABS.
Product Specifications
Hygromycin B
Formula: C20H37N3O13
MW: 527.52 g/mol
Storage/Handling: Store desiccated at -20°C.
PubChem Chemical ID: 35766
N.B.
International shipments MUST be shipped by air (including Canada and Mexico). Shipments of 25 g, 50 g and 100 g will be shipped as multiples of 25 g units to qualify for the small quantity exception. 500 g pack sizes are a hazardous shipment and will incur a hazmat fee, which we estimate to be $65.
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