CSF2 (GM-CSF), Murine

Product Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Murine Colony Stimulating Factor 2 (granulocyte-macrophage)
CSF2
GM-CSF, GMCSF
Molgramostin
MGI-1GM (Macrophage granulocyte inducer-1GM)

Colony Stimulating Factor 2 (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types, including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts, in response to cytokine or immune and inflammatory stimuli. On mature hematopoietic cells, CSF2 is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages and eosinophils. CSF2 promotes a Th1 biased immune response, angiogenesis, allergic inflammation and the development of autoimmunity. It shows clinical effectiveness in ameliorating chemotherapy-induced neutropenia, and CSF2 transfected tumor cells are utilized as cancer vaccines. Mature mouse CSF2 shares 49% - 54% amino acid sequence identity with canine, feline, human, and porcine CSF2 and 69% with rat CSF2. The activity of CSF2 is species specific between human and mouse. Mouse CSF2 is only weakly active on rat cells, although rat CSF2 is fully active on mouse cells.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~14.2 kDa (124 amino acid)

Purity: >95% by SDS-PAGE and HPLC analyses

Storage/Handling: Store desiccated at -20°C.

Mouse Genome Database ID: 1339752

NOT FOR HUMAN USE!

Cross-species homology


Percent Similarity

HuCSF2 MuCSF2 RtCSF2
HuCSF2 *** 54.7 63.3
MuCSF2 *** *** 69.5
RtCSF2 *** *** ***

Additional resources for this protein may be found at:
OMIM

Product Specifications

Catalog ID 1320-03
MW ~14.2 kDa
Storage/Handling Store desiccated at -20°C.

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