Brefeldin A

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Description

Brefeldin A is an antibiotic derived from Penicillium brefeldianum. It is an anti-cancer agent which disrupts protein transport and causes apoptosis of tumor cells. Brefeldin A disrupts the function of the Golgi apparatus and blocks Golgi-COPI activity. ER vesicles are prevented from fusion with the Golgi and are secretion is inhibited. Additionally, Brefeldin A is an ARF inhibitor, sphingomyelin cycle activator, and caspase-3 activator. It has been shown to induce apoptosis in leukemia cells and colon cancer cells.

Product Specifications
Brefeldin A

MOLECULAR BIOLOGY GRADE

Formula: C16H24O4

MW: 280.36 g/mol

Storage/Handling: Store at 4°C.

Brefeldin A is soluble in DMSO, acetone, or ethanol. It is insoluble in water.

PubChem CID: 5287620

Brefeldin A

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Catalog Number:
B-930-5
CAS Number:
20350-15-6
$123.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
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$14.99 Ground shipping (In continental US only.)

    Description

    Brefeldin A is an antibiotic derived from Penicillium brefeldianum. It is an anti-cancer agent which disrupts protein transport and causes apoptosis of tumor cells. Brefeldin A disrupts the function of the Golgi apparatus and blocks Golgi-COPI activity. ER vesicles are prevented from fusion with the Golgi and are secretion is inhibited. Additionally, Brefeldin A is an ARF inhibitor, sphingomyelin cycle activator, and caspase-3 activator. It has been shown to induce apoptosis in leukemia cells and colon cancer cells.

    Product Specifications
    Brefeldin A

    MOLECULAR BIOLOGY GRADE

    Formula: C16H24O4

    MW: 280.36 g/mol

    Storage/Handling: Store at 4°C.

    Brefeldin A is soluble in DMSO, acetone, or ethanol. It is insoluble in water.

    PubChem CID: 5287620

    Product Specifications

    Catalog ID: B-930
    CAS #: 20350-15-6
    Formula: C16H24O4
    MW: 280.36 g/mol
    Grade: MOLECULAR BIOLOGY GRADE
    Storage/handling: Store at 4°C.
    UN number: 2811
    group number: III
    item class: 6.1
    PubChem Chemical ID: 5287620
    IUPAC Name: (1R,2R,3E,7S,11E,13S,15S)-2,15-dihydroxy-7-methyl-6-oxabicyclo[11.3.0]hexadeca-3,11-dien-5-one
    InChI: InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1
    InChIKey: KQNZDYYTLMIZCT-KQPMLPITSA-N
    SMILES: CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O

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