Description
Cefaclor is a second generation cephalosporin antibiotic isolated from the Acremonium fungus. It targets a wide variety of bacteria including Streptococcus pneumoniae and Haemophilus influenzae and a variety of other gram-negative and gram-positive bacteria. In addition, cefaclor has been useful in studying urinary tract and intra-abdominal infections and the mechanisms of renal transporters hOTA1, hPEPT1, and hPEPT2.
Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.
Product Specifications
Cefaclor
MOLECULAR BIOLOGY GRADE
Formula: C15H14ClN3O4S
MW: 367.81 g/mol
Storage/Handling: Store at room temperature.
PubChem Chemical ID: 51039
