Cefuroxime Sodium

Product Description

Cefuroxime is a second generation cephalosporin antibiotic targeting gram-positive and gram-negative bacteria. It exhibits some resistance to β-lactamase activity. Cefuroxime sodium is freely soluble in aqueous solution.

Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Cefuroxime Sodium

MOLECULAR BIOLOGY GRADE

Formula: C16H15N4NaO8S

MW: 446.37 g/mol

Storage/Handling: Store at 2-8°C.

PubChem Chemical ID: 23670318

Product Specifications

Catalog ID C-790
CAS # 56238-63-2
MW 446.37 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C.

Technical Documentation

P Protocol
O Other
C Certificate of Analysis
S Safety Data Sheet

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