Erlotinib HCl

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Description

Erlotinib HCl is an anti-cancer agent targeting epidermal growth factor receptor (EGFR) tyrosine kinase ATP binding sites, which are commonly overexpressed and sometimes mutated in a variety of cancers. Erlotinib prevents the formation of EGFR homodimers leading to suppression of signal transmittance and tumor growth inhibition. Additionally, erlotinib suppresses cyclin-dependent kinase 2 (Cdk2). It has been shown to be effective against non-small cell lung cancer and pancreatic cancer.

Product Specifications
Erlotinib HCl
Tarceva®

MOLECULAR BIOLOGY GRADE

Formula: C22H23N3O4

MW: 393.44 g/mol

Storage/Handling: Store at 2-8 °C. Product is soluble in acid (pH 2) at 0.4 mg/mL.

PubChem Chemical ID: 176870

Air shipments may require special packaging and a small additional box charge.

Erlotinib HCl

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Catalog Number:
E-270-100
CAS Number:
183321-74-6
$123.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Erlotinib HCl is an anti-cancer agent targeting epidermal growth factor receptor (EGFR) tyrosine kinase ATP binding sites, which are commonly overexpressed and sometimes mutated in a variety of cancers. Erlotinib prevents the formation of EGFR homodimers leading to suppression of signal transmittance and tumor growth inhibition. Additionally, erlotinib suppresses cyclin-dependent kinase 2 (Cdk2). It has been shown to be effective against non-small cell lung cancer and pancreatic cancer.

    Product Specifications
    Erlotinib HCl
    Tarceva®

    MOLECULAR BIOLOGY GRADE

    Formula: C22H23N3O4

    MW: 393.44 g/mol

    Storage/Handling: Store at 2-8 °C. Product is soluble in acid (pH 2) at 0.4 mg/mL.

    PubChem Chemical ID: 176870

    Air shipments may require special packaging and a small additional box charge.

    Product Specifications

    Catalog ID: E-270
    CAS #: 183321-74-6
    Formula: C22H23N3O4
    MW: 393.44 g/mol
    Grade: MOLECULAR BIOLOGY GRADE
    Storage/handling: Store at 4°C.
    PubChem Chemical ID: 176870
    IUPAC Name: N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
    InChI: InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)
    InChIKey: AAKJLRGGTJKAMG-UHFFFAOYSA-N
    SMILES: COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC

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