Description
Imipenem is a carbapenem β-lactam antibiotic with a broad target spectrum. It has been shown to be effective against ESBL-producing Enterobacteriaceae and gram-negative and gram-positive organisms. Imipenem has also been shown to be effective against bacteria from the genus Burkholderia. Resistance to imipenem is conferred through the loss of the OprD porin protein.
β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.
Product Specifications
Imipenem
Imipenem Monohydrate
MOLECULAR BIOLOGY GRADE
Formula: C12H17N3O4S ∙ H2O
MW: 317.36 g/mol
Storage/Handling: Store at -20°C.
PubChem Chemical ID: 5282372
