Methicillin Sodium

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Description

Methicillin is β-lactam antibiotic of the penicillin family. It has a narrow-spectrum, primarily targeting gram-positive bacteria such as Staphylococcus aureus. It is often used to study susceptibility and resistance of bacteria to antimicrobials, especially methicillin-resistance in Staphylococcus aureus. Methicillin is inactivated by gastric acid.

Penicillins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a five-membered thiazolidine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Resistance to β-lactam antibiotics occurs in the presence of cells containing plasmid encoded extended spectrum β-lactamases or ESBLs.


Product Specifications
Methicillin Sodium

MOLECULAR BIOLOGY GRADE

Formula: C17H19N2NaO6S

MW: 402.40 g/mol

Storage/Handling: Store at -20°C. Product is light sensitive.

PubChem Chemical ID: 23667627

Methicillin Sodium

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Catalog Number:
M-830-100
CAS Number:
132-92-3
$94.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Methicillin is β-lactam antibiotic of the penicillin family. It has a narrow-spectrum, primarily targeting gram-positive bacteria such as Staphylococcus aureus. It is often used to study susceptibility and resistance of bacteria to antimicrobials, especially methicillin-resistance in Staphylococcus aureus. Methicillin is inactivated by gastric acid.

    Penicillins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a five-membered thiazolidine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Resistance to β-lactam antibiotics occurs in the presence of cells containing plasmid encoded extended spectrum β-lactamases or ESBLs.


    Product Specifications
    Methicillin Sodium

    MOLECULAR BIOLOGY GRADE

    Formula: C17H19N2NaO6S

    MW: 402.40 g/mol

    Storage/Handling: Store at -20°C. Product is light sensitive.

    PubChem Chemical ID: 23667627

    Product Specifications

    Catalog ID: M-830
    CAS #: 132-92-3
    Formula: C17H19N2NaO6S
    MW: 402.40 g/mol
    Grade: MOLECULAR BIOLOGY GRADE
    Storage/handling: Store at -20°C.
    PubChem Chemical ID: 23667627
    IUPAC Name: sodium (2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
    InChI: InChI=1S/C17H20N2O6S.Na/c1-17(2)12(16(22)23)19-14(21)11(15(19)26-17)18-13(20)10-8(24-3)6-5-7-9(10)25-4;/h5-7,11-12,15H,1-4H3,(H,18,20)(H,22,23);/q;+1/p-1/t11-,12+,15-;/m1./s1
    InChIKey: MGFZNWDWOKASQZ-UMLIZJHQSA-M
    SMILES: CC1(C(N2C(S1)C(C2=O)NC(=O)C3=C(C=CC=C3OC)OC)C(=O)[O-])C.[Na+]

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