Norfloxacin is a first generation fluoroquinolone antibiotic targeting primarily gram-negative bacteria responsible for causing urinary tract infections. It is a derivative of pefloxacin.
Fluoroquinolones are a group of broad-spectrum antibiotics that inhibit DNA synthesis. These antibiotics prevent unwinding of double-stranded DNA by binding DNA gyrase or DNA topoisomerase. By preventing the formation of single-stranded DNA, fluoroquinolones inhibit bacterial replication.
Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
MOLECULAR BIOLOGY GRADE
MW: 319.33 g/mol
Storage/Handling: Store at 4°C. Protect from light.
PubChem Chemical ID: 4539
|Grade||MOLECULAR BIOLOGY GRADE|
|Storage/Handling||Store at 4°C.|