Amoxicillin/Clavulanate

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Description

Amoxicillin/Clavulanate combines an extended-spectrum β-lactam antibiotic with a β-lactamase inhibitor. Amoxicillin is an extended-spectrum ß-lactam antibiotic with a structure similar to that of ampicillin. It is effective against a variety of ß-lactamase negative bacteria including E. coli and various Streptococcus and Staphylococcus bacteria; however, when combined with clavulanic acid, ß-lactamase enzymes are irreversibly inactivated. Consequently, amoxicillin/clavulanate is effective against ß-lactamase-negative and ß-lactamase-positive bacteria.

Penicillins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a five-membered thiazolidine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Resistance to β-lactam antibiotics occurs in the presence of cells containing plasmid encoded extended spectrum β-lactamases or ESBLs.


Product Specifications
Amoxicillin/ Clavulanate
Augmentin® (by GSK)

MOLECULAR BIOLOGY GRADE

Formula: C24H27KN4O10S

MW: 602.66 g/mol

Storage/Handling: Store desiccated at 2-8°C.

PubChem Chemical ID: 23665637

Amoxicillin/Clavulanate

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Catalog Number:
A-552-1
CAS Number:
34642-77-8; 61177-45-5
$86.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Amoxicillin/Clavulanate combines an extended-spectrum β-lactam antibiotic with a β-lactamase inhibitor. Amoxicillin is an extended-spectrum ß-lactam antibiotic with a structure similar to that of ampicillin. It is effective against a variety of ß-lactamase negative bacteria including E. coli and various Streptococcus and Staphylococcus bacteria; however, when combined with clavulanic acid, ß-lactamase enzymes are irreversibly inactivated. Consequently, amoxicillin/clavulanate is effective against ß-lactamase-negative and ß-lactamase-positive bacteria.

    Penicillins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a five-membered thiazolidine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Resistance to β-lactam antibiotics occurs in the presence of cells containing plasmid encoded extended spectrum β-lactamases or ESBLs.


    Product Specifications
    Amoxicillin/ Clavulanate
    Augmentin® (by GSK)

    MOLECULAR BIOLOGY GRADE

    Formula: C24H27KN4O10S

    MW: 602.66 g/mol

    Storage/Handling: Store desiccated at 2-8°C.

    PubChem Chemical ID: 23665637

    Product Specifications

    Catalog ID: A-552
    CAS #: 34642-77-8; 61177-45-5
    MW: 602.66 g/mol
    Grade: MOLECULAR BIOLOGY GRADE
    Storage/handling: Store desiccated at 4°C.
    PubChem Chemical ID: 23695837
    IUPAC Name: potassium;(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;(3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate
    InChI: InChI=1S/C16H19N3O5S.C8H9NO5.K/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);1,6-7,10H,2-3H2,(H,12,13);/q;;+1/p-1/b;4-1-;/t9-,10-,11+,14-;6-,7?;/m11./s1
    InChIKey: DWHGNUUWCJZQHO-VXMVAJKNSA-M
    SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)C(=O)O)C.C1[C@@H]2N(C1=O)C(/C(=C/CO)/O2)C(=O)[O-].[K+]

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