Cefpodoxime Proxetil

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Description

Cefpodoxime proxetil is a third generation cephalosporin antibiotic targeting a wide variety of gram-negative and gram-positive organisms, especially those responsible for otitis media and pharyngitis. It is an ester prodrug of the free acid metabolite cefpodoxime.

Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.


Product Specifications
Cefpodoxime Proxetil
Vantin® (Pfizer), Simplicef® (Pfizer)

MOLECULAR BIOLOGY GRADE

Formula: C21H27N5O9S2

MW: 557.60 g/mol

Storage/Handling: Store at 2-8 °C. This product is light sensitive. Soluble in DMSO.

PubChem Chemical ID: 6526396

Cefpodoxime Proxetil

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Catalog Number:
C-710-100
CAS Number:
87239-81-4
$123.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Cefpodoxime proxetil is a third generation cephalosporin antibiotic targeting a wide variety of gram-negative and gram-positive organisms, especially those responsible for otitis media and pharyngitis. It is an ester prodrug of the free acid metabolite cefpodoxime.

    Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.


    Product Specifications
    Cefpodoxime Proxetil
    Vantin® (Pfizer), Simplicef® (Pfizer)

    MOLECULAR BIOLOGY GRADE

    Formula: C21H27N5O9S2

    MW: 557.60 g/mol

    Storage/Handling: Store at 2-8 °C. This product is light sensitive. Soluble in DMSO.

    PubChem Chemical ID: 6526396

    Product Specifications

    Catalog ID: C-710
    CAS #: 87239-81-4
    MW: 557.60 g/mol
    Grade: MOLECULAR BIOLOGY GRADE
    Storage/handling: Store at 4°C.
    PubChem Chemical ID: 6526396
    IUPAC Name: 1-propan-2-yloxycarbonyloxyethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    InChI: InChI=1S/C21H27N5O9S2/c1-9(2)33-21(30)35-10(3)34-19(29)15-11(6-31-4)7-36-18-14(17(28)26(15)18)24-16(27)13(25-32-5)12-8-37-20(22)23-12/h8-10,14,18H,6-7H2,1-5H3,(H2,22,23)(H,24,27)/b25-13-/t10?,14-,18-/m1/s1
    InChIKey: LTINZAODLRIQIX-FBXRGJNPSA-N
    SMILES: CC(C)OC(=O)OC(C)OC(=O)C1=C(CSC2N1C(=O)C2NC(=O)C(=NOC)C3=CSC(=N3)N)COC

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