Description
Flucloxacillin sodium is a narrow-spectrum penicillin antibiotic similar to cloxacillin. Resistant to β-lactamases, it targets gram-positive organisms such as Staphylococcus aureus. It can causes cholestatic liver damage.
Penicillins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a five-membered thiazolidine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Resistance to β-lactam antibiotics occurs in the presence of cells containing plasmid encoded extended spectrum β-lactamases or ESBLs, however flucloxacillin is resistant to these effects.
Product Specifications
Flucloxacillin Sodium
MOLECULAR BIOLOGY GRADE
Formula: C19H16ClFN3NaO5S
MW: 475.85 g/mol
Storage/Handling: Store in a dry and well-ventilated place.
PubChem Chemical ID: 23667629
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