Ceftazidime Pentahydrate

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Description

Ceftazidime pentahydrate is a third generation cephalosporin antibiotic. It has been used to study the penicillin binding proteins, especially PBP3. It has also been used as a selection tool for mutant colonies. Ceftazidime targets gram-negative bacteria, including Pseudomonas aeruginosa and is less effective against gram-positive cocci. It is soluble in acidic and alkali solvents.

Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.


Product Specifications
Ceftazidime Pentahydrate

MOLECULAR BIOLOGY GRADE

Formula: C22H22N6O7S2 ∙ 5H2O

MW: 636.65 g/mol

Storage/Handling: Store at 2-8 °C.

PubChem Chemical ID: 6536864

Ceftazidime Pentahydrate

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Catalog Number:
C-740-2.5
CAS Number:
78439-06-2
$165.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
In stock
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Ceftazidime pentahydrate is a third generation cephalosporin antibiotic. It has been used to study the penicillin binding proteins, especially PBP3. It has also been used as a selection tool for mutant colonies. Ceftazidime targets gram-negative bacteria, including Pseudomonas aeruginosa and is less effective against gram-positive cocci. It is soluble in acidic and alkali solvents.

    Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.


    Product Specifications
    Ceftazidime Pentahydrate

    MOLECULAR BIOLOGY GRADE

    Formula: C22H22N6O7S2 ∙ 5H2O

    MW: 636.65 g/mol

    Storage/Handling: Store at 2-8 °C.

    PubChem Chemical ID: 6536864

    Product Specifications

    Catalog ID: C-740
    CAS #: 78439-06-2
    MW: 636.65 g/mol
    Grade: MOLECULAR BIOLOGY GRADE
    Storage/handling: Store at 4°C.
    PubChem Chemical ID: 6536864
    IUPAC Name: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;pentahydrate
    InChI: InChI=1S/C22H22N6O7S2.5H2O/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27;;;;;/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34);5*1H2/b26-13-;;;;;/t14-,18-;;;;;/m1...../s1
    InChIKey: NMVPEQXCMGEDNH-TZVUEUGBSA-N
    SMILES: CC(C)(C(=O)O)ON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC=CC=C4)C(=O)[O-].O.O.O.O.O

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